biostudies-literatureUnknownMorse KNICHD NIH HHSNIGMS NIH HHSAlternative transcription start sites can affect transcript isoform diversity and translation levels. In a recently described form of gene regulation, coordinated transcriptional and translational interference results in transcript isoform-dependent changes in protein expression. Specifically, a long undecoded transcript isoform (LUTI) is transcribed from a gene-distal promoter, interfering with expression of the gene-proximal promoter. While transcriptional and chromatin features associated with LUTI expression have been described, the mechanism underlying LUTI-based transcriptional interference is not well understood. Using an unbiased genetic approach followed by integrated genomic analysis, we uncovered that the Swi/Snf chromatin remodeling complex is required for co-transcriptional nubioRxiv : the preprint server for biology2023.04.27.538572https://www.ebi.ac.uk/biostudies/studies/S-EPMC10168381biostudies-literatureSwi/Snf Chromatin Remodeling Regulates Transcriptional Interference and Gene Repression.PMC10168381F31 HD103399R01 GM140005Swerdlow SMorse KUnal EfalseSwi/Snf Chromatin Remodeling Regulates Transcriptional Interference and Gene Repression.Alternative transcription start sites can affect transcript isoform diversity and translation levels. In a recently described form of gene regulation, coordinated transcriptional and translational interference results in transcript isoform-dependent changes in protein expression. Specifically, a long undecoded transcript isoform (LUTI) is transcribed from a gene-distal promoter, interfering with expression of the gene-proximal promoter. While transcriptional and chromatin features associated with LUTI expression have been described, the mechanism underlying LUTI-based transcriptional interference is not well understood. Using an unbiased genetic approach followed by integrated genomic analysis, we uncovered that the Swi/Snf chromatin remodeling complex is required for co-transcriptional nu2023-01-01T00:00:00Z2023 Apr2026-05-16T03:16:01.637Z2025-04-04T10:24:07.561ZS-EPMC101683813716293110.1101/2023.04.27.538572