{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fu S"],"funding":["National Natural Science Foundation of China"],"pagination":["43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10169343"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(1)"],"pubmed_abstract":["<h4>Background</h4>Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficient multicomponent nanobased drug delivery systems (DDS). Here, our study presents the screening and development of a novel DDS based on co-assemblies natural small molecule (NSMs). These molecules (oleanolic acid, and betulinic acid) are combined with photosensitizers Chlorine6 (Ce6) and Cu<sup>2+</sup> that are encapsulated by tumor cell membranes. This nanocarrier encapsulated in tumor cell membranes achieved good tumor targeting and a "],"journal":["Biomaterials research"],"pubmed_title":["Bionic natural small molecule co-assemblies towards targeted and synergistic Chemo/PDT/CDT."],"pmcid":["PMC10169343"],"funding_grant_id":["31972040"],"pubmed_authors":["Wang M","Yang X","Li X","Fu S","Lu W","Zhang H","Li B","Dong A","Cheng J","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Bionic natural small molecule co-assemblies towards targeted and synergistic Chemo/PDT/CDT.","description":"<h4>Background</h4>Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficient multicomponent nanobased drug delivery systems (DDS). Here, our study presents the screening and development of a novel DDS based on co-assemblies natural small molecule (NSMs). These molecules (oleanolic acid, and betulinic acid) are combined with photosensitizers Chlorine6 (Ce6) and Cu<sup>2+</sup> that are encapsulated by tumor cell membranes. This nanocarrier encapsulated in tumor cell membranes achieved good tumor targeting and a ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-22T14:39:10.814Z","creation":"2025-04-06T01:06:59.74Z"},"accession":"S-EPMC10169343","cross_references":{"pubmed":["37161611"],"doi":["10.1186/s40824-023-00380-z"]}}