biostudies-literatureFu SNational Natural Science Foundation of China43https://www.ebi.ac.uk/biostudies/studies/S-EPMC10169343biostudies-literatureUnknown27(1)<h4>Background</h4>Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficient multicomponent nanobased drug delivery systems (DDS). Here, our study presents the screening and development of a novel DDS based on co-assemblies natural small molecule (NSMs). These molecules (oleanolic acid, and betulinic acid) are combined with photosensitizers Chlorine6 (Ce6) and Cu²⁺ that are encapsulated by tumor cell membranes. This nanocarrier encapsulated in tumor cell membranes achieved good tumor targeting and a Biomaterials researchBionic natural small molecule co-assemblies towards targeted and synergistic Chemo/PDT/CDT.PMC1016934331972040Wang MYang XLi XFu SLu WZhang HLi BDong ACheng JZhao HfalseBionic natural small molecule co-assemblies towards targeted and synergistic Chemo/PDT/CDT.<h4>Background</h4>Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficient multicomponent nanobased drug delivery systems (DDS). Here, our study presents the screening and development of a novel DDS based on co-assemblies natural small molecule (NSMs). These molecules (oleanolic acid, and betulinic acid) are combined with photosensitizers Chlorine6 (Ce6) and Cu²⁺ that are encapsulated by tumor cell membranes. This nanocarrier encapsulated in tumor cell membranes achieved good tumor targeting and a 2023-01-01T00:00:00Z2023 May2025-04-22T14:39:10.814Z2025-04-06T01:06:59.74ZS-EPMC101693433716161110.1186/s40824-023-00380-z