biostudies-literatureMuiru ANNational Institute of Neurological Disorders and StrokeEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute on Alcohol Abuse and AlcoholismNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Nursing ResearchNational Heart, Lung, and Blood InstituteNational Institute on Deafness and Other Communication DisordersOntario Ministry of Health and Long-Term CareNational Institutes of HealthHealth Resources and Services AdministrationNational Human Genome Research InstituteCanadian Institutes of Health ResearchNational Institute on AgingNational Institute of Allergy and Infectious DiseasesAgency for Healthcare Research and QualityCenters for Disease Control and PreventionNIDDK NIH HHSNational Cancer InstituteNational Institute of Mental HealthNational Institute of Dental and Craniofacial ResearchNational Institute on Drug Abuse461-468https://www.ebi.ac.uk/biostudies/studies/S-EPMC10169400biostudies-literatureUnknown76(3)<h4>Background</h4>The impact of adopting a race-free estimated glomerular filtration rate (eGFR) creatinine (eGFRcr) equation on racial differences in chronic kidney disease (CKD) progression among people with human immunodeficiency virus (PWH) is unknown.<h4>Methods</h4>We defined eGFR stages using the original race-adjusted Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFRcr equation and the new race-free CKD-EPI eGFRcr equation. We then estimated 5-year probabilities of transitioning from baseline kidney function to more advanced eGFR stages and examined the association of race (black vs white) with rates of CKD progression using Markov models.<h4>Results</h4>With the race-adjusted eGFRcr equation, black participants (n = 31 298) had a lower risk of progressing from eGFRClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaEffect of Adopting the New Race-Free 2021 Chronic Kidney Disease Epidemiology Collaboration Estimated Glomerular Filtration Rate Creatinine Equation on Racial Differences in Kidney Disease Progression Among People With Human Immunodeficiency Virus: An Observational Study.PMC10169400K23 DK119562K23EY013707P30MH62246U01HL146208R24AI067039U01AI038855U10EY008067U01HL146333U01AI069918U01AI038858CDC-200-2006-18797K24AI118591F31DA037788U01AI069434UL1RR024131TGF-96118R01AA016893CBR-94036HCP-97105U54GM133807P30AI036219U10EY008057N02CP055504U01AI068636U01AA020790G12MD007583K24DA035684U01AI068634R01DA012568KL2TR000421F31AI124794U01DA03629U10EY008052CDC-200-2015-63931K24DA000432R01DA026770P30AI050409U24AA020794P30AI050410P30AI110527U01DA036935N01CP01004U01HL146194P30AI027757U01HL146193U01HL146192R01 AG053100U01AI06943290051652UL1TR000004UL1TR000083CBR-86906K01AI131895K01AI093197R01DA011602N02CP91027P30AI02776390047713Z01CP010176U01HL146205U01HL146204U01HL146203U01HL146202U01HL146201U01HL146245Z01CP010214U01HL146242U01HL146241P30AI094189U01HL146240U01AA013566K24AI065298P30AI027767Klein MBShlipak MGMayor AMKoethe JRNapravnik SCrane HMMadden EJohn Gill MScherzer REstrella MMMarconi VCMuiru ANLucas GMAlthoff KNAbraham AGHorberg MASilverberg MJMoore RDfalseEffect of Adopting the New Race-Free 2021 Chronic Kidney Disease Epidemiology Collaboration Estimated Glomerular Filtration Rate Creatinine Equation on Racial Differences in Kidney Disease Progression Among People With Human Immunodeficiency Virus: An Observational Study.<h4>Background</h4>The impact of adopting a race-free estimated glomerular filtration rate (eGFR) creatinine (eGFRcr) equation on racial differences in chronic kidney disease (CKD) progression among people with human immunodeficiency virus (PWH) is unknown.<h4>Methods</h4>We defined eGFR stages using the original race-adjusted Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFRcr equation and the new race-free CKD-EPI eGFRcr equation. We then estimated 5-year probabilities of transitioning from baseline kidney function to more advanced eGFR stages and examined the association of race (black vs white) with rates of CKD progression using Markov models.<h4>Results</h4>With the race-adjusted eGFRcr equation, black participants (n = 31 298) had a lower risk of progressing from eGFR2023-01-01T00:00:00Z2023 Feb2025-04-26T14:27:42.387Z2025-04-06T14:33:21.131ZS-EPMC101694003606906410.1093/cid/ciac731