biostudies-literatureUnknown76(3)Manion MNational Institute of Allergy and Infectious DiseaseNIHIn the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America531-534https://www.ebi.ac.uk/biostudies/studies/S-EPMC10169433biostudies-literaturePolyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome.PMC10169433Laidlaw EKuriakose SBoulougoura ANaqvi NDeepe GRupert ASereti ITadros SRoby GRichards EPau ASheikh VAnderson MOrtega-Villa AMManion MGrivas CLage SLGalindo FfalsePolyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome.In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.2023-01-01T00:00:00Z2023 Feb2026-04-08T03:16:11.334Z2025-04-06T14:35:09.119ZS-EPMC101694333576727210.1093/cid/ciac514