{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pilat AV"],"funding":["Medical Research Council","RCUK | Medical Research Council","Ulverscroft Foundation"],"pagination":["1496-1502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10169844"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(7)"],"pubmed_abstract":["<h4>Purpose</h4>To quantify in patients with optic nerve head drusen (ONHD)changes after 1-year observation in: (i) optic disc and (ii) macular optical coherence tomography (OCT) parameters and (iii) the effect of age at enrolment in the study.<h4>Design</h4>Prospective, cross-sectional observational study using Spectral Domain-OCT (Copernicus; OPTOPOL Technology S.A., Zawiercie, Poland) imaging was carried out in 35 patients with ONHD (age-42.8 ± 19.9 years; males = 15; females = 20) at baseline and after 12 months follow-up.<h4>Results</h4>Patients with ONHD had significant thinning of the surface nerve fibre layer in the central (p = 0.03), superior (p = 0.05) and inferior (p = 0.04) areas; mean ppRNFL thinning (p = 0.0 4) and ppRNFL thinning in the nasal segment (p = 0.028). Retinal th"],"journal":["Eye (London, England)"],"pubmed_title":["Short-term progression of optic disc and macular changes in optic nerve head drusen."],"pmcid":["PMC10169844"],"funding_grant_id":["MR/J004189/1","MC_PC_17171","MR/N004566/1"],"pubmed_authors":["Gottlob I","Proudlock FA","Pilat AV","Kumar P"],"additional_accession":[]},"is_claimable":false,"name":"Short-term progression of optic disc and macular changes in optic nerve head drusen.","description":"<h4>Purpose</h4>To quantify in patients with optic nerve head drusen (ONHD)changes after 1-year observation in: (i) optic disc and (ii) macular optical coherence tomography (OCT) parameters and (iii) the effect of age at enrolment in the study.<h4>Design</h4>Prospective, cross-sectional observational study using Spectral Domain-OCT (Copernicus; OPTOPOL Technology S.A., Zawiercie, Poland) imaging was carried out in 35 patients with ONHD (age-42.8 ± 19.9 years; males = 15; females = 20) at baseline and after 12 months follow-up.<h4>Results</h4>Patients with ONHD had significant thinning of the surface nerve fibre layer in the central (p = 0.03), superior (p = 0.05) and inferior (p = 0.04) areas; mean ppRNFL thinning (p = 0.0 4) and ppRNFL thinning in the nasal segment (p = 0.028). Retinal th","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-22T08:48:10.846Z","creation":"2025-04-05T22:41:52.802Z"},"accession":"S-EPMC10169844","cross_references":{"pubmed":["35842539"],"doi":["10.1038/s41433-022-02155-7"]}}