biostudies-literaturePilat AVMedical Research CouncilRCUK | Medical Research CouncilUlverscroft Foundation1496-1502https://www.ebi.ac.uk/biostudies/studies/S-EPMC10169844biostudies-literatureUnknown37(7)<h4>Purpose</h4>To quantify in patients with optic nerve head drusen (ONHD)changes after 1-year observation in: (i) optic disc and (ii) macular optical coherence tomography (OCT) parameters and (iii) the effect of age at enrolment in the study.<h4>Design</h4>Prospective, cross-sectional observational study using Spectral Domain-OCT (Copernicus; OPTOPOL Technology S.A., Zawiercie, Poland) imaging was carried out in 35 patients with ONHD (age-42.8 ± 19.9 years; males = 15; females = 20) at baseline and after 12 months follow-up.<h4>Results</h4>Patients with ONHD had significant thinning of the surface nerve fibre layer in the central (p = 0.03), superior (p = 0.05) and inferior (p = 0.04) areas; mean ppRNFL thinning (p = 0.0 4) and ppRNFL thinning in the nasal segment (p = 0.028). Retinal thEye (London, England)Short-term progression of optic disc and macular changes in optic nerve head drusen.PMC10169844MR/J004189/1MC_PC_17171MR/N004566/1Gottlob IProudlock FAPilat AVKumar PfalseShort-term progression of optic disc and macular changes in optic nerve head drusen.<h4>Purpose</h4>To quantify in patients with optic nerve head drusen (ONHD)changes after 1-year observation in: (i) optic disc and (ii) macular optical coherence tomography (OCT) parameters and (iii) the effect of age at enrolment in the study.<h4>Design</h4>Prospective, cross-sectional observational study using Spectral Domain-OCT (Copernicus; OPTOPOL Technology S.A., Zawiercie, Poland) imaging was carried out in 35 patients with ONHD (age-42.8 ± 19.9 years; males = 15; females = 20) at baseline and after 12 months follow-up.<h4>Results</h4>Patients with ONHD had significant thinning of the surface nerve fibre layer in the central (p = 0.03), superior (p = 0.05) and inferior (p = 0.04) areas; mean ppRNFL thinning (p = 0.0 4) and ppRNFL thinning in the nasal segment (p = 0.028). Retinal th2023-01-01T00:00:00Z2023 May2025-04-22T08:48:10.846Z2025-04-05T22:41:52.802ZS-EPMC101698443584253910.1038/s41433-022-02155-7