{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Yanan L"],"pubmed_abstract":["Head and neck squamous cell carcinoma (HNSCC) is a common tumour type in otorhinolaryngology, and its occurrence is related to long-term exposure to tobacco and alcohol. Recently, HPV infection has become an increasingly important contributor to HNSCC, and HPV-associated HNSCC has a different clinical course and better prognosis than non-HPV-associated HNSCC. However, the exact molecular mechanism of HNSCC is unclear. Here, we obtained data from The Cancer Genome Atlas (TCGA) and gene expression omnibus (GEO) to analyse the mitophagy process and related influencing factors of HPV-associated HNSCC via the integration of bioinformatics analysis and experimental validation. We found that in HPV-associated HNSCC, process of mitophagy affects tumour development, immune cell infiltration and pro"],"journal":["Scientific reports"],"pagination":["7480"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10170109"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensive analysis of mitophagy in HPV-related head and neck squamous cell carcinoma."],"pmcid":["PMC10170109"],"pubmed_authors":["Yanan L","Ran S","Hui L","Longqing D","Zhuo C"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of mitophagy in HPV-related head and neck squamous cell carcinoma.","description":"Head and neck squamous cell carcinoma (HNSCC) is a common tumour type in otorhinolaryngology, and its occurrence is related to long-term exposure to tobacco and alcohol. Recently, HPV infection has become an increasingly important contributor to HNSCC, and HPV-associated HNSCC has a different clinical course and better prognosis than non-HPV-associated HNSCC. However, the exact molecular mechanism of HNSCC is unclear. Here, we obtained data from The Cancer Genome Atlas (TCGA) and gene expression omnibus (GEO) to analyse the mitophagy process and related influencing factors of HPV-associated HNSCC via the integration of bioinformatics analysis and experimental validation. We found that in HPV-associated HNSCC, process of mitophagy affects tumour development, immune cell infiltration and pro","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-05T18:50:12.801Z","creation":"2025-04-05T18:50:12.801Z"},"accession":"S-EPMC10170109","cross_references":{"pubmed":["37161060"],"doi":["10.1038/s41598-023-34698-4"]}}