biostudies-literatureUnknown13(1)Ai MPrior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While a multidomain lifestyle provides an ecological perspective to voluntary engagement, its association with brain health is still under-investigated. Therefore, understanding the neural mechanisms underlying multidomain lifestyle engagement, particularly in older adults at risk for Alzheimer's disease (AD), gives valuable insights into providing lifestyle advice and intervention for those in need. The current study included 139 healthy older adults with familial risk for AD from the Prevent-AD longitudinal aging cohort. Self-reported exercise engagement, cognitive activity engagement, healthy diet adherence, and social activity engagement were included Scientific reports7487https://www.ebi.ac.uk/biostudies/studies/S-EPMC10170147biostudies-literatureResting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer's disease.PMC10170147Breitner JCSPogossova GGervais VZhang JLafaille-Magnan MESager MAPoirier JGordon RSpreng NWhitfield-Gabrieli SWan KFrenette JCouture DHoge RFonov VGiles RFontaine DMunter LMKat JKostopoulos PLabonte APREVENT-AD Research GroupPage VGeddes MRIturia-Medina YBinette APRioux PKramer AFVenugopalan VMathieu AKazazian CPetkova MVilleneuve SLeoutsakos JMCheewakriengkrai LBenbouhoud FAppleby MFerdinand FRajah NDadar MMayrand GAisen PAnthal ECraft SKligman SRosa-Neto PGreco CAi MFrancoeur RBohbot VBrunelle CSoucy JPSt-Onge FGagne GVachon-Presseau ESperling RASaint-Fort EFLee TMulthaup GBrandt JGauthier SToussaint PJDesrochers NEl-Khoury RWang SMiron JVallee IMaltais JREvans ADuclair GNear JTardif CTremblay-Mercier JMathotaarachchi SMichaud DDufour MNewbold-Fox HDaoust LAMorris TPEisenberg MBellec PHudon LNilsson NTheroux LTuwaig MPicard CDas SChakravarty MEtienne PFaubert AMDauar-Tedeschi MMcSweeney MNair VMadjar CLeppert Ide la Colina ANPascoal TARemz JSavard MMeyer PFDea DMorris JCDubuc SMahar LCollins LGonneaud JThomas RGfalseResting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer's disease.Prior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While a multidomain lifestyle provides an ecological perspective to voluntary engagement, its association with brain health is still under-investigated. Therefore, understanding the neural mechanisms underlying multidomain lifestyle engagement, particularly in older adults at risk for Alzheimer's disease (AD), gives valuable insights into providing lifestyle advice and intervention for those in need. The current study included 139 healthy older adults with familial risk for AD from the Prevent-AD longitudinal aging cohort. Self-reported exercise engagement, cognitive activity engagement, healthy diet adherence, and social activity engagement were included 2023-01-01T00:00:00Z2023 May2025-04-21T22:42:53.778Z2025-04-05T18:51:45.194ZS-EPMC101701473716091510.1038/s41598-023-32714-1