{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Talukdar D"],"funding":["Council of Scientific and Industrial Research, India","Department of Biotechnology, Ministry of Science and Technology, India"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10170741"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Severe coronavirus disease 2019 (COVID-19) is associated with systemic hyper-inflammation. An adaptive interaction between gut microbiota and host immune systems is important for intestinal homeostasis and systemic immune regulation. The association of gut microbial composition and functions with COVID-19 disease severity is sparse, especially in India. We analysed faecal microbial diversity and abundances in a cohort of Indian COVID-19 patients to identify key signatures in the gut microbial ecology in patients with severe COVID-19 disease as well as in response to different therapies. The composition of the gut microbiome was characterized using 16Sr RNA gene sequences of genomic DNA extracted from faecal samples of 52 COVID-19 patients. Metabolic pathways across the g"],"journal":["Gut pathogens"],"pubmed_title":["Association of gut microbial dysbiosis with disease severity, response to therapy and disease outcomes in Indian patients with COVID-19."],"pmcid":["PMC10170741"],"funding_grant_id":["MLP-129","BT/PR38173/MED/97/474/2020"],"pubmed_authors":["Talukdar D","D'Rozario R","Ray Y","Ganguly D","Lahiri A","Das B","Bandopadhyay P","Das S","Sarif J","Bhowmick D","Chatterjee S","Paul SR"],"additional_accession":[]},"is_claimable":false,"name":"Association of gut microbial dysbiosis with disease severity, response to therapy and disease outcomes in Indian patients with COVID-19.","description":"<h4>Background</h4>Severe coronavirus disease 2019 (COVID-19) is associated with systemic hyper-inflammation. An adaptive interaction between gut microbiota and host immune systems is important for intestinal homeostasis and systemic immune regulation. The association of gut microbial composition and functions with COVID-19 disease severity is sparse, especially in India. We analysed faecal microbial diversity and abundances in a cohort of Indian COVID-19 patients to identify key signatures in the gut microbial ecology in patients with severe COVID-19 disease as well as in response to different therapies. The composition of the gut microbiome was characterized using 16Sr RNA gene sequences of genomic DNA extracted from faecal samples of 52 COVID-19 patients. Metabolic pathways across the g","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-26T01:40:19.132Z","creation":"2025-04-06T10:14:08.053Z"},"accession":"S-EPMC10170741","cross_references":{"pubmed":["37161621"],"doi":["10.1186/s13099-023-00546-z"]}}