{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Francou A"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","The Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center of MSKCC","NCI NIH HHS","National Institutes of Health"],"pagination":["e84019"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10171865"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Epithelial-to-mesenchymal transition (EMT) is a fundamental process whereby epithelial cells acquire mesenchymal phenotypes and the ability to migrate. EMT is the hallmark of gastrulation, an evolutionarily conserved developmental process. In mammals, epiblast cells ingress at the primitive streak to form mesoderm. Cells ingress and exit the epiblast epithelial layer and the associated EMT is dynamically regulated and involves a stereotypical sequence of cell behaviors. 3D time-lapse imaging of gastrulating mouse embryos combined with cell and tissue scale data analyses revealed the asynchronous ingression of epiblast cells at the primitive streak. Ingressing cells constrict their apical surfaces in a pulsed ratchet-like fashion through asynchronous shrinkage of apical junctions. A quantit"],"journal":["eLife"],"pubmed_title":["A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT."],"pmcid":["PMC10171865"],"funding_grant_id":["R01DK127821","R01HD086478","P30 CA008748","R01 DK127821","P30CA008748","R01 HD086478","Postdoctoral Fellowship","R01 HD094868","R01HD094868"],"pubmed_authors":["Francou A","Anderson KV","Hadjantonakis AK"],"additional_accession":[]},"is_claimable":false,"name":"A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT.","description":"Epithelial-to-mesenchymal transition (EMT) is a fundamental process whereby epithelial cells acquire mesenchymal phenotypes and the ability to migrate. EMT is the hallmark of gastrulation, an evolutionarily conserved developmental process. In mammals, epiblast cells ingress at the primitive streak to form mesoderm. Cells ingress and exit the epiblast epithelial layer and the associated EMT is dynamically regulated and involves a stereotypical sequence of cell behaviors. 3D time-lapse imaging of gastrulating mouse embryos combined with cell and tissue scale data analyses revealed the asynchronous ingression of epiblast cells at the primitive streak. Ingressing cells constrict their apical surfaces in a pulsed ratchet-like fashion through asynchronous shrinkage of apical junctions. A quantit","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-25T22:33:17.092Z","creation":"2025-02-19T01:48:01.549Z"},"accession":"S-EPMC10171865","cross_references":{"pubmed":["37162187"],"doi":["10.7554/eLife.84019"]}}