{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(5)"],"submitter":["Ressing M"],"funding":["Deutsche Krebshilfe"],"pubmed_abstract":["<h4>Background</h4>Epidemiological research on late effects of therapy shows the necessity to aggregate chemotherapy agents to substance classes. This requires using conversion factors by substance classes.<h4>Aims</h4>The aim of this study was to identify previously used conversion factors from the literature, to present a novel approach for additional factors, and to compare these approaches.<h4>Methods and results</h4>A literature review was performed, which identified two main principles of deriving conversion factors: effect-equivalence and equimolar. Thirty-five articles presenting effect equivalence-based factors in the widest sense were found in the literature. Ten articles presented the equimolar approach which can be applied to almost all chemotherapy substances. Based on a compr"],"journal":["Cancer reports (Hoboken, N.J.)"],"pagination":["e1811"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10172172"],"repository":["biostudies-literature"],"pubmed_title":["Equivalent doses for anticancer agents used in pediatric oncology: A literature review and evaluation of a novel approach for conversion factors."],"pmcid":["PMC10172172"],"pubmed_authors":["Erdmann F","Voigt M","Spix C","Mahmoudpour SH","Muller C","Langer T","Blettner M","Ressing M","Calaminus G","Becker C","Kaiser M","Kaatsch P"],"additional_accession":[]},"is_claimable":false,"name":"Equivalent doses for anticancer agents used in pediatric oncology: A literature review and evaluation of a novel approach for conversion factors.","description":"<h4>Background</h4>Epidemiological research on late effects of therapy shows the necessity to aggregate chemotherapy agents to substance classes. This requires using conversion factors by substance classes.<h4>Aims</h4>The aim of this study was to identify previously used conversion factors from the literature, to present a novel approach for additional factors, and to compare these approaches.<h4>Methods and results</h4>A literature review was performed, which identified two main principles of deriving conversion factors: effect-equivalence and equimolar. Thirty-five articles presenting effect equivalence-based factors in the widest sense were found in the literature. Ten articles presented the equimolar approach which can be applied to almost all chemotherapy substances. Based on a compr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-22T00:26:25.36Z","creation":"2025-04-05T19:37:39.785Z"},"accession":"S-EPMC10172172","cross_references":{"pubmed":["36975206"],"doi":["10.1002/cnr2.1811"]}}