biostudies-literatureUnknown6(5)Ressing MDeutsche Krebshilfe<h4>Background</h4>Epidemiological research on late effects of therapy shows the necessity to aggregate chemotherapy agents to substance classes. This requires using conversion factors by substance classes.<h4>Aims</h4>The aim of this study was to identify previously used conversion factors from the literature, to present a novel approach for additional factors, and to compare these approaches.<h4>Methods and results</h4>A literature review was performed, which identified two main principles of deriving conversion factors: effect-equivalence and equimolar. Thirty-five articles presenting effect equivalence-based factors in the widest sense were found in the literature. Ten articles presented the equimolar approach which can be applied to almost all chemotherapy substances. Based on a comprCancer reports (Hoboken, N.J.)e1811https://www.ebi.ac.uk/biostudies/studies/S-EPMC10172172biostudies-literatureEquivalent doses for anticancer agents used in pediatric oncology: A literature review and evaluation of a novel approach for conversion factors.PMC10172172Erdmann FVoigt MSpix CMahmoudpour SHMuller CLanger TBlettner MRessing MCalaminus GBecker CKaiser MKaatsch PfalseEquivalent doses for anticancer agents used in pediatric oncology: A literature review and evaluation of a novel approach for conversion factors.<h4>Background</h4>Epidemiological research on late effects of therapy shows the necessity to aggregate chemotherapy agents to substance classes. This requires using conversion factors by substance classes.<h4>Aims</h4>The aim of this study was to identify previously used conversion factors from the literature, to present a novel approach for additional factors, and to compare these approaches.<h4>Methods and results</h4>A literature review was performed, which identified two main principles of deriving conversion factors: effect-equivalence and equimolar. Thirty-five articles presenting effect equivalence-based factors in the widest sense were found in the literature. Ten articles presented the equimolar approach which can be applied to almost all chemotherapy substances. Based on a compr2023-01-01T00:00:00Z2023 May2025-04-22T00:26:25.36Z2025-04-05T19:37:39.785ZS-EPMC101721723697520610.1002/cnr2.1811