biostudies-literatureHuang TFundamental Research Funds for Central Universities of the Central South UniversityNational Natural Science Foundation of ChinaChangsha Science and Technology Project1-12https://www.ebi.ac.uk/biostudies/studies/S-EPMC10173072biostudies-literatureUnknown40<h4>Background</h4>Although neuroregulation plays an important role in tissue healing, the key neuroregulatory pathways and related neurotransmitters involved in bone-tendon interface (BTI) healing are still unknown. It is reported that sympathetic nerves can regulate cartilage and bone metabolism, which are the basic aspects of BTI repair after injury, through the release of norepinephrine (NE). Thus, the purpose of this study was to explore the effect of local sympatholysis (LS) on BTI healing in a murine rotator cuff repair model.<h4>Methods</h4>Specifically, C57BL/6 mice underwent unilateral supraspinatus tendon (SST) detachment and repair was established on a total of 174 mature C57BL/6 mice (12 weeks old): 54 mice were used to examine the sympathetic fibers and its neurotransmitter NJournal of orthopaedic translationThe effect of local sympatholysis on bone-tendon interface healing in a murine rotator cuff repair model.PMC10173072kh21020158173006882272572822300852022ZZTS0880Xiong YYuan FHuang THuang JLu HWan LChen YXie SfalseThe effect of local sympatholysis on bone-tendon interface healing in a murine rotator cuff repair model.<h4>Background</h4>Although neuroregulation plays an important role in tissue healing, the key neuroregulatory pathways and related neurotransmitters involved in bone-tendon interface (BTI) healing are still unknown. It is reported that sympathetic nerves can regulate cartilage and bone metabolism, which are the basic aspects of BTI repair after injury, through the release of norepinephrine (NE). Thus, the purpose of this study was to explore the effect of local sympatholysis (LS) on BTI healing in a murine rotator cuff repair model.<h4>Methods</h4>Specifically, C57BL/6 mice underwent unilateral supraspinatus tendon (SST) detachment and repair was established on a total of 174 mature C57BL/6 mice (12 weeks old): 54 mice were used to examine the sympathetic fibers and its neurotransmitter N2023-01-01T00:00:00Z2023 May2026-07-14T21:13:12.703Z2025-04-06T09:03:38.749ZS-EPMC101730723718148010.1016/j.jot.2023.03.001