{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhuang J"],"funding":["the Guangdong Medical Research Fund","the Open project of the Key Laboratory of Male Reproduction and Genetics of the National Health Commission","Guangdong Basic and Applied Basic Research Foundation","Basic and Applied Basic Research Foundation of Guangdong Province","National Natural Science Foundation of China","Guangdong Provincial Reproductive Science Institute Innovation Team grants"],"pagination":["21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10173474"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Morphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation. And we have previously demonstrated that the epididymal initial segment (IS), a region of the reproductive tract essential for sperm maturation and capacitation, undergoes considerable histological changes and chronic immune activation in mice during aging. However, the local aging-associated cellular and molecular changes in the aged epididymal IS are poorly understood.<h4>Results</h4>We conducted single-cell RNA sequencing analysis on the epididymal IS of young (3-month-old) and old (21-month-old) mice. In total, 10,027 cells from the epididymal IS tissues of young and old mice "],"journal":["Immunity & ageing : I & A"],"pubmed_title":["Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging."],"pmcid":["PMC10173474"],"funding_grant_id":["KF202001","Nos. 2020A1515111160, 2021A1515110986 and 2020A1515110735","No.C-03","Nos. B2021333 and B2021453","Nos.82101819 and 82101664"],"pubmed_authors":["Liu H","Li X","Yao J","Liu J","Hu Y","Xie Y","Qin W","Sun X","Zhuang J","Nie H","Tu X"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging.","description":"<h4>Background</h4>Morphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation. And we have previously demonstrated that the epididymal initial segment (IS), a region of the reproductive tract essential for sperm maturation and capacitation, undergoes considerable histological changes and chronic immune activation in mice during aging. However, the local aging-associated cellular and molecular changes in the aged epididymal IS are poorly understood.<h4>Results</h4>We conducted single-cell RNA sequencing analysis on the epididymal IS of young (3-month-old) and old (21-month-old) mice. In total, 10,027 cells from the epididymal IS tissues of young and old mice ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-22T14:40:07.587Z","creation":"2025-04-06T01:07:58.223Z"},"accession":"S-EPMC10173474","cross_references":{"pubmed":["37170325"],"doi":["10.1186/s12979-023-00345-9"]}}