{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mijit M"],"funding":["NEI NIH HHS","NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health"],"pagination":["1146115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10174294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is characterized by a profound inflammatory tumor microenvironment (TME) with high heterogeneity, metastatic propensity, and extreme hypoxia. The integrated stress response (ISR) pathway features a family of protein kinases that phosphorylate eukaryotic initiation factor 2 (eIF2) and regulate translation in response to diverse stress conditions, including hypoxia. We previously demonstrated that eIF2 signaling pathways were profoundly affected in response to Redox factor-1 (Ref-1) knockdown in human PDAC cells. Ref-1 is a dual function enzyme with activities of DNA repair and redox signaling, responds to cellular stress, and regulates survival pathways. The redox function of Ref-1 directly regulates multiple transcription factors"],"journal":["Frontiers in medicine"],"pubmed_title":["Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment."],"pmcid":["PMC10174294"],"funding_grant_id":["R01 CA282478","P30 CA082709","R01 CA167291","R01 HL140961","R01 CA205166","R01 EY031939","R01 CA231267","U01 CA274304","U01 HL143403"],"pubmed_authors":["Gampala S","Kelley MR","Staschke KA","Mijit M","Klunk AJ","Fishel ML","Boner M","Kpenu E","Cordova RA","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment.","description":"Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is characterized by a profound inflammatory tumor microenvironment (TME) with high heterogeneity, metastatic propensity, and extreme hypoxia. The integrated stress response (ISR) pathway features a family of protein kinases that phosphorylate eukaryotic initiation factor 2 (eIF2) and regulate translation in response to diverse stress conditions, including hypoxia. We previously demonstrated that eIF2 signaling pathways were profoundly affected in response to Redox factor-1 (Ref-1) knockdown in human PDAC cells. Ref-1 is a dual function enzyme with activities of DNA repair and redox signaling, responds to cellular stress, and regulates survival pathways. The redox function of Ref-1 directly regulates multiple transcription factors","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-28T23:00:17.027Z","creation":"2026-04-08T03:24:41.116Z"},"accession":"S-EPMC10174294","cross_references":{"pubmed":["37181357"],"doi":["10.3389/fmed.2023.1146115"]}}