biostudies-literatureNicolai LEuropean Research CouncilDeutsche ForschungsgemeinschaftDeutsches Zentrum für Herz-KreislaufforschungDeutsche Herzstiftung2020-2031https://www.ebi.ac.uk/biostudies/studies/S-EPMC10174338biostudies-literatureUnknown21(8)Long COVID is a public health emergency affecting millions of people worldwide, characterized by heterogeneous symptoms across multiple organ systems. Here, we discuss the current evidence linking thromboinflammation to postacute sequelae of COVID-19. Studies have found persistence of vascular damage with increased circulating markers of endothelial dysfunction, coagulation abnormalities with heightened thrombin generation capacity, and abnormalities in platelet counts in postacute sequelae of COVID-19. Neutrophil phenotype resembles acute COVID-19 with an increase in activation and Neutrophil Extracellular Trap formation. These insights are potentially linked by elevated platelet-neutrophil aggregate formation. This hypercoagulable state in turn can lead to microvascular thrombosis, evideJournal of thrombosis and haemostasis : JTHThromboinflammation in long COVID-the elusive key to postinfection sequelae?PMC10174338512460086B06A07413635475SFB 1123Stark KKaiser RNicolai LfalseThromboinflammation in long COVID-the elusive key to postinfection sequelae?Long COVID is a public health emergency affecting millions of people worldwide, characterized by heterogeneous symptoms across multiple organ systems. Here, we discuss the current evidence linking thromboinflammation to postacute sequelae of COVID-19. Studies have found persistence of vascular damage with increased circulating markers of endothelial dysfunction, coagulation abnormalities with heightened thrombin generation capacity, and abnormalities in platelet counts in postacute sequelae of COVID-19. Neutrophil phenotype resembles acute COVID-19 with an increase in activation and Neutrophil Extracellular Trap formation. These insights are potentially linked by elevated platelet-neutrophil aggregate formation. This hypercoagulable state in turn can lead to microvascular thrombosis, evide2023-01-01T00:00:00Z2023 Aug2025-04-19T03:47:23.463Z2024-11-09T21:34:32.438ZS-EPMC101743383717876910.1016/j.jtha.2023.04.039