{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pita T"],"funding":["Fundação para a Ciência e a Tecnologia","Universidade de Lisboa"],"pagination":["3653-3671"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10175445"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(11)"],"pubmed_abstract":["Small non-coding RNAs (sRNAs) are key regulators of post-transcriptional gene expression in bacteria. Despite the identification of hundreds of bacterial sRNAs, their roles on bacterial physiology and virulence remain largely unknown, as is the case of bacteria of the Burkholderia cepacia complex (Bcc). Bcc is a group of opportunistic pathogens with relatively large genomes that can cause lethal lung infections amongst cystic fibrosis (CF) patients. To characterise sRNAs expressed by Bcc bacteria when infecting a host, the nematode Caenorhabditis elegans was used as an infection model by the epidemic CF strain B. cenocepacia J2315. A total of 108 new and 31 previously described sRNAs with a predicted Rho independent terminator were identified, most of them located on chromosome 1. RIT11b, "],"journal":["Applied microbiology and biotechnology"],"pubmed_title":["Identification of Burkholderia cenocepacia non-coding RNAs expressed during Caenorhabditis elegans infection."],"pmcid":["PMC10175445"],"funding_grant_id":["UIDB/04565/2020","2022.07091.PTDC","LA/P/0140/2020","PD/BD/135137/2017","UIDP/04565/2020","PTDC/BIA-MIC/1615/2014"],"pubmed_authors":["Pita T","Feliciano JR","Leitao JH"],"additional_accession":[]},"is_claimable":false,"name":"Identification of Burkholderia cenocepacia non-coding RNAs expressed during Caenorhabditis elegans infection.","description":"Small non-coding RNAs (sRNAs) are key regulators of post-transcriptional gene expression in bacteria. Despite the identification of hundreds of bacterial sRNAs, their roles on bacterial physiology and virulence remain largely unknown, as is the case of bacteria of the Burkholderia cepacia complex (Bcc). Bcc is a group of opportunistic pathogens with relatively large genomes that can cause lethal lung infections amongst cystic fibrosis (CF) patients. To characterise sRNAs expressed by Bcc bacteria when infecting a host, the nematode Caenorhabditis elegans was used as an infection model by the epidemic CF strain B. cenocepacia J2315. A total of 108 new and 31 previously described sRNAs with a predicted Rho independent terminator were identified, most of them located on chromosome 1. RIT11b, ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-06-02T16:16:31.997Z","creation":"2025-04-04T13:50:37.36Z"},"accession":"S-EPMC10175445","cross_references":{"pubmed":["37097504"],"doi":["10.1007/s00253-023-12530-3"]}}