biostudies-literatureLugli GAMinistero della SaluteScience Foundation Ireland25https://www.ebi.ac.uk/biostudies/studies/S-EPMC10175488biostudies-literatureUnknown9(1)During infancy, gut microbiota development is a crucial process involved in the establishment of microbe-host interactions which may persist throughout adulthood, and which are believed to influence host health. To fully understand the complexities of such interactions, it is essential to assess gut microbiota diversity of newborns and its associated microbial dynamics and relationships pertaining to health and disease. To explore microbial biodiversity during the first 3 years of human life, 10,935 shotgun metagenomic datasets were taxonomically and functionally classified. Microbial species distribution between infants revealed the presence of eight major Infant Community State Types (ICSTs), being dominated by 17 bacterial taxa, whose distribution was shown to correspond to the geographNPJ biofilms and microbiomesComprehensive insights from composition to functional microbe-based biodiversity of the infant human gut microbiota.PMC10175488SFI/12/RC/2273aGR-2018-12365988Milani CTurroni FMancabelli LVentura MAlessandri GLugli GAFontana FTarracchini Cvan Sinderen DfalseComprehensive insights from composition to functional microbe-based biodiversity of the infant human gut microbiota.During infancy, gut microbiota development is a crucial process involved in the establishment of microbe-host interactions which may persist throughout adulthood, and which are believed to influence host health. To fully understand the complexities of such interactions, it is essential to assess gut microbiota diversity of newborns and its associated microbial dynamics and relationships pertaining to health and disease. To explore microbial biodiversity during the first 3 years of human life, 10,935 shotgun metagenomic datasets were taxonomically and functionally classified. Microbial species distribution between infants revealed the presence of eight major Infant Community State Types (ICSTs), being dominated by 17 bacterial taxa, whose distribution was shown to correspond to the geograph2023-01-01T00:00:00Z2023 May2025-04-18T15:12:44.514Z2025-04-07T01:51:43.06ZS-EPMC101754883716978610.1038/s41522-023-00392-6