biostudies-literatureTsujimoto KJapan Agency for Medical Research and Development - Core Research for Evolution Science and Technology (AMED-CREST)Japan Society for the Promotion of ScienceJapan Agency for Medical Research and Development (AMED)28https://www.ebi.ac.uk/biostudies/studies/S-EPMC10175929biostudies-literatureUnknown43(1)Our understanding of lysosomes has undergone a significant transformation in recent years, from the view that they are static organelles primarily responsible for the disposal and recycling of cellular waste to their recognition as highly dynamic structures. Current research posits that lysosomes function as a signaling hub that integrates both extracellular and intracellular stimuli, thereby regulating cellular homeostasis. The dysregulation of lysosomal function has been linked to a wide range of diseases. Of note, lysosomes contribute to the activation of mammalian target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism. The Ragulator complex, a protein complex anchored on the lysosomal membrane, was initially shown to tether the mTORC1 complex to lysosomes. RecenInflammation and regenerationThe Ragulator complex: delving its multifunctional impact on metabolism and beyond.PMC1017592922gm1810003h0001JP18H0528223K14544223fa627002h0001Tsujimoto KTakamatsu HKumanogoh AfalseThe Ragulator complex: delving its multifunctional impact on metabolism and beyond.Our understanding of lysosomes has undergone a significant transformation in recent years, from the view that they are static organelles primarily responsible for the disposal and recycling of cellular waste to their recognition as highly dynamic structures. Current research posits that lysosomes function as a signaling hub that integrates both extracellular and intracellular stimuli, thereby regulating cellular homeostasis. The dysregulation of lysosomal function has been linked to a wide range of diseases. Of note, lysosomes contribute to the activation of mammalian target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism. The Ragulator complex, a protein complex anchored on the lysosomal membrane, was initially shown to tether the mTORC1 complex to lysosomes. Recen2023-01-01T00:00:00Z2023 May2025-04-04T10:19:45.646Z2025-02-19T00:12:22.799ZS-EPMC101759293717375510.1186/s41232-023-00278-2