{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Wang J"],"pubmed_abstract":["Effectively reducing the inflammatory response after spinal cord injury (SCI) is a challenging clinical problem and the subject of active investigation. This study employed a porous scaffold-based three dimensional long-term culture technique to obtain human umbilical cord mesenchymal stem cell (hUC-MSC)-derived Small Extracellular Vesicles (sEVs) (three dimensional culture over time, the \"4D-sEVs\"). Moreover, the vesicle size, number, and inner protein concentrations of the MSC 4D-sEVs contained altered protein profiles compared with those derived from 2D culture conditions. A proteomics analysis suggested broad changes, especially significant upregulation of Epidermal Growth Factors Receptor (EGFR) and Insulin-like Growth Factor Binding Protein 2 (IGFBP2) in 4D-sEVs compared with 2D-sEVs"],"journal":["Frontiers in bioengineering and biotechnology"],"pagination":["1146981"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10176095"],"repository":["biostudies-literature"],"pubmed_title":["Small extracellular vesicles derived from four dimensional-culture of mesenchymal stem cells induce alternatively activated macrophages by upregulating IGFBP2/EGFR to attenuate inflammation in the spinal cord injury of rats."],"pmcid":["PMC10176095"],"pubmed_authors":["He G","Ma Y","Zeng X","Wang J","Che M","Yu H","Zeng T","Ma W","Yang Y","Wei Q","Wu R","Peng L","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Small extracellular vesicles derived from four dimensional-culture of mesenchymal stem cells induce alternatively activated macrophages by upregulating IGFBP2/EGFR to attenuate inflammation in the spinal cord injury of rats.","description":"Effectively reducing the inflammatory response after spinal cord injury (SCI) is a challenging clinical problem and the subject of active investigation. This study employed a porous scaffold-based three dimensional long-term culture technique to obtain human umbilical cord mesenchymal stem cell (hUC-MSC)-derived Small Extracellular Vesicles (sEVs) (three dimensional culture over time, the \"4D-sEVs\"). Moreover, the vesicle size, number, and inner protein concentrations of the MSC 4D-sEVs contained altered protein profiles compared with those derived from 2D culture conditions. A proteomics analysis suggested broad changes, especially significant upregulation of Epidermal Growth Factors Receptor (EGFR) and Insulin-like Growth Factor Binding Protein 2 (IGFBP2) in 4D-sEVs compared with 2D-sEVs","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-26T14:30:23.26Z","creation":"2025-04-06T14:35:13.989Z"},"accession":"S-EPMC10176095","cross_references":{"pubmed":["37187882"],"doi":["10.3389/fbioe.2023.1146981"]}}