biostudies-literatureUnknown10Dong R<h4>Introduction</h4>Excessive calorie intake and physical inactivity have dramatically increased nutrient overload-associated disease, becoming a global public health issue. <i>Chimonanthus salicifolius</i> S. Y. Hu (<i>CHI</i>) is a homology plant of food and medicine in China and shows several health benefits.<h4>Methods</h4>This work investigated the antioxidant activity, the alleviating effects, and the mechanism of action on diabetes and hyperlipidemia of <i>CHI</i> leaves.<h4>Results and discussion</h4>Results showed that <i>CHI</i> leaves infusion displayed <i>in vitro</i> antioxidant activity measured by ABTS and ferric reducing antioxidant power methods. In wild-type Kunming mice, <i>CHI</i> leaves infusion consumption activated the hepatic antioxidant enzymes, including glutathiFrontiers in nutrition1168049https://www.ebi.ac.uk/biostudies/studies/S-EPMC10176510biostudies-literatureAntioxidant, antihyperglycemic, and antihyperlipidemic properties of <i>Chimonanthus salicifolius</i> S. Y. Hu leaves in experimental animals: modulation of thioredoxin and glutathione systems, renal water reabsorption, and gut microbiota.PMC10176510Miao SWang DYing JWu FDong RLi NBan QSong LPan JZhao QWang SHuang XGranato DZhao GCheng KfalseAntioxidant, antihyperglycemic, and antihyperlipidemic properties of <i>Chimonanthus salicifolius</i> S. Y. Hu leaves in experimental animals: modulation of thioredoxin and glutathione systems, renal water reabsorption, and gut microbiota.<h4>Introduction</h4>Excessive calorie intake and physical inactivity have dramatically increased nutrient overload-associated disease, becoming a global public health issue. <i>Chimonanthus salicifolius</i> S. Y. Hu (<i>CHI</i>) is a homology plant of food and medicine in China and shows several health benefits.<h4>Methods</h4>This work investigated the antioxidant activity, the alleviating effects, and the mechanism of action on diabetes and hyperlipidemia of <i>CHI</i> leaves.<h4>Results and discussion</h4>Results showed that <i>CHI</i> leaves infusion displayed <i>in vitro</i> antioxidant activity measured by ABTS and ferric reducing antioxidant power methods. In wild-type Kunming mice, <i>CHI</i> leaves infusion consumption activated the hepatic antioxidant enzymes, including glutathi2023-01-01T00:00:00Z20232026-05-28T13:50:11.62Z2024-11-10T04:10:57.578ZS-EPMC101765103718787510.3389/fnut.2023.1168049