biostudies-literatureMohammadi EEuropean Research CouncilDutch Research Council (NWO)3978-3984https://www.ebi.ac.uk/biostudies/studies/S-EPMC10176573biostudies-literatureUnknown23(9)Nanophotonics can boost the weak circular dichroism of chiral molecules. One mechanism for enhanced chiral sensing relies on using a resonator to create fields with high optical chirality at the molecular position. Here, we elucidate how the reverse interaction between molecules and the resonator, called chirality transfer, can produce stronger circular dichroism. The chiral analyte modifies the electric and magnetic dipole moments of the resonator, imprinting a chiral response on an otherwise achiral resonance. We demonstrate that silicon nanoparticles and metasurfaces tailored for chirality transfer generate chiroptical signals orders of magnitude higher than the contribution from optical chirality alone. We derive closed-form equations for the dependence of chirality transfer on moleculNano lettersNanophotonic Chirality Transfer to Dielectric Mie Resonators.PMC10176573948804740.018.009Raziman TVMohammadi ECurto AGfalseNanophotonic Chirality Transfer to Dielectric Mie Resonators.Nanophotonics can boost the weak circular dichroism of chiral molecules. One mechanism for enhanced chiral sensing relies on using a resonator to create fields with high optical chirality at the molecular position. Here, we elucidate how the reverse interaction between molecules and the resonator, called chirality transfer, can produce stronger circular dichroism. The chiral analyte modifies the electric and magnetic dipole moments of the resonator, imprinting a chiral response on an otherwise achiral resonance. We demonstrate that silicon nanoparticles and metasurfaces tailored for chirality transfer generate chiroptical signals orders of magnitude higher than the contribution from optical chirality alone. We derive closed-form equations for the dependence of chirality transfer on molecul2023-01-01T00:00:00Z2023 May2025-04-25T22:29:24.089Z2025-04-06T09:05:39.031ZS-EPMC101765733712664010.1021/acs.nanolett.3c00739