{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(9)"],"submitter":["Oh S"],"pubmed_abstract":["Poly-L-lactic acid (PLLA) fillers correct cutaneous volume loss by stimulating fibroblasts to synthesize collagen and by augmenting the volume. PLLA triggers the macrophage-induced activation of fibroblasts that secrete transforming growth factor-β (TGF-β). However, whether M2 macrophage polarization is involved in PLLA-induced collagen synthesis via fibroblast activation in aged skin is not known. Therefore, we evaluated the effect of PLLA on dermal collagen synthesis via M2 polarization in an H<sub>2</sub>O<sub>2</sub>-induced cellular senescence model and aged animal skin. H<sub>2</sub>O<sub>2</sub>-treated macrophages had increased expression levels of the M1 marker CD80 and decreased expression levels of the M2 marker CD163, which were reversed by PLLA. The expression levels of interl"],"journal":["Cells"],"pagination":["1320"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10177436"],"repository":["biostudies-literature"],"pubmed_title":["Poly-L-Lactic Acid Fillers Improved Dermal Collagen Synthesis by Modulating M2 Macrophage Polarization in Aged Animal Skin."],"pmcid":["PMC10177436"],"pubmed_authors":["Lee MH","Kim HM","Byun K","Oh S","Sung MJ","Son KH","Batsukh S","Lim TH","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Poly-L-Lactic Acid Fillers Improved Dermal Collagen Synthesis by Modulating M2 Macrophage Polarization in Aged Animal Skin.","description":"Poly-L-lactic acid (PLLA) fillers correct cutaneous volume loss by stimulating fibroblasts to synthesize collagen and by augmenting the volume. PLLA triggers the macrophage-induced activation of fibroblasts that secrete transforming growth factor-β (TGF-β). However, whether M2 macrophage polarization is involved in PLLA-induced collagen synthesis via fibroblast activation in aged skin is not known. Therefore, we evaluated the effect of PLLA on dermal collagen synthesis via M2 polarization in an H<sub>2</sub>O<sub>2</sub>-induced cellular senescence model and aged animal skin. H<sub>2</sub>O<sub>2</sub>-treated macrophages had increased expression levels of the M1 marker CD80 and decreased expression levels of the M2 marker CD163, which were reversed by PLLA. The expression levels of interl","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-05T16:14:23.644Z","creation":"2025-04-05T16:14:23.644Z"},"accession":"S-EPMC10177436","cross_references":{"pubmed":["37174720"],"doi":["10.3390/cells12091320"]}}