biostudies-literatureLlorente XSpanish Ministry of Science and Innovation8053https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179084biostudies-literatureUnknown24(9)Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of the most effective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative effects potentially beneficial for diseases with excessive cell turnover. However, RLZ possesses low water solubility and high light-sensibility. We present here optimized NLCs loaded with RLZ (RLZ-NLCs) as a potential topical treatment. RLZ-NLCs were prepared by the hot-pressure homogenization method using active essential oils as liquid lipids, and optimized using the design of experiments approach. RLZ-NLCs were developed obtaining optimInternational journal of molecular sciencesRiluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases.PMC10179084PID2021-122187NB-C32PID2021-126249OA-I00PID2020-114477RB-I00Bonilla LAgudelo MGLlorente XManils JSanchez-Lopez EGarcia MLPujol MLopez-Ramajo DSoler CEspina MGong RCFilgaira IEsteruelas GfalseRiluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases.Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of the most effective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative effects potentially beneficial for diseases with excessive cell turnover. However, RLZ possesses low water solubility and high light-sensibility. We present here optimized NLCs loaded with RLZ (RLZ-NLCs) as a potential topical treatment. RLZ-NLCs were prepared by the hot-pressure homogenization method using active essential oils as liquid lipids, and optimized using the design of experiments approach. RLZ-NLCs were developed obtaining optim2023-01-01T00:00:00Z2023 Apr2025-04-18T13:56:57.821Z2025-04-06T23:49:27.842ZS-EPMC101790843717576510.3390/ijms24098053