{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ferdousi F"],"funding":["MED R&D Corporation, Japan","Japan Science and Technology-OPERA program","MED R&D Corporation","Japan Science and Technology Agency","NIPPN Corporation","NIPPN Corporation, Japan"],"pagination":["8077"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179098"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(9)"],"pubmed_abstract":["Carnosic acid (CA) is a phenolic diterpene widely distributed in herbal plants, rosemary and sage. Although its medicinal properties, such as antioxidant, antimicrobial, and neuroprotective effects, have been well-documented, its relevant biochemical processes and molecular targets have not been fully explored yet. In the present study, we conducted an untargeted whole-genome transcriptomics analysis to investigate CA-induced early biological and molecular events in human amniotic epithelial stem cells (hAESCs) with the aim of exploring its multiple tissue-specific functionalities and potential molecular targets. We found that seven days of CA treatment in hAESCs could induce mesoderm-lineage-specific differentiation. Tissue enrichment analysis revealed that CA significantly enriched later"],"journal":["International journal of molecular sciences"],"pubmed_title":["A Descriptive Whole-Genome Transcriptomics Study in a Stem Cell-Based Tool Predicts Multiple Tissue-Specific Beneficial Potential and Molecular Targets of Carnosic Acid."],"pmcid":["PMC10179098"],"funding_grant_id":["N/A","JPMJPF2017","JPMJOP 1832"],"pubmed_authors":["Sasaki K","Isoda H","Kuwata H","Ferdousi F","Nakajima M","Fukumitsu S"],"additional_accession":[]},"is_claimable":false,"name":"A Descriptive Whole-Genome Transcriptomics Study in a Stem Cell-Based Tool Predicts Multiple Tissue-Specific Beneficial Potential and Molecular Targets of Carnosic Acid.","description":"Carnosic acid (CA) is a phenolic diterpene widely distributed in herbal plants, rosemary and sage. Although its medicinal properties, such as antioxidant, antimicrobial, and neuroprotective effects, have been well-documented, its relevant biochemical processes and molecular targets have not been fully explored yet. In the present study, we conducted an untargeted whole-genome transcriptomics analysis to investigate CA-induced early biological and molecular events in human amniotic epithelial stem cells (hAESCs) with the aim of exploring its multiple tissue-specific functionalities and potential molecular targets. We found that seven days of CA treatment in hAESCs could induce mesoderm-lineage-specific differentiation. Tissue enrichment analysis revealed that CA significantly enriched later","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-17T03:15:03.933Z","creation":"2024-11-15T19:59:09.518Z"},"accession":"S-EPMC10179098","cross_references":{"pubmed":["37175790"],"doi":["10.3390/ijms24098077"]}}