biostudies-literatureUnknown24(9)Mohammadnezhad LPrimary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells' signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells' signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with BCR has revealed that targeting <i>CD79A</i>, <i>CD79B</i>, and <i>LAMTOR4</i> as the shared genes can provide novel biomarkers for pSS progression into lymphoma.International journal of molecular sciences8385https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179133biostudies-literatureB-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma.PMC10179133Mohammadnezhad LDieli FGuggino GShekarkar Azgomi MBotta CLa Manna MPCaccamo NfalseB-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma.Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells' signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells' signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with BCR has revealed that targeting <i>CD79A</i>, <i>CD79B</i>, and <i>LAMTOR4</i> as the shared genes can provide novel biomarkers for pSS progression into lymphoma.2023-01-01T00:00:00Z2023 May2024-11-21T05:38:12.166Z2024-11-21T05:38:12.166ZS-EPMC101791333717609210.3390/ijms24098385