{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Serrat J"],"funding":["Instituto de Salud Carlos III","Ministerio de Ciencia, Innovación y Universidades (MCIU), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, UE)","Spanish Ministry of Science and Innovation","Junta de Castilla y León","Junta de Castilla y León and the European Regional Development Fund","Junta de Castilla y León and the European Union (FEDER \"Europe drives our growth\")","Ministerio de Ciencia e Innovación","Ministerio de Ciencia","Instituto de Salud Carlos III (ISCIII) and the European Regional Development Fund (ERDF)","European Regional Development Fund"],"pagination":["8165"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179147"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(9)"],"pubmed_abstract":["<i>Fasciola hepatica</i> is the main causative agent of fasciolosis, a zoonotic parasitic disease of growing public health concern. <i>F. hepatica</i> metacercariae are ingested by the host and excyst in the intestine, thereby releasing the newly excysted juveniles (FhNEJ), which traverse the gut wall and migrate towards the biliary ducts. Since blocking <i>F. hepatica</i> development is challenging after crossing of the intestinal wall, targeting this first step of migration might result in increased therapeutic success. The intestinal extracellular matrix (ECM) is constituted by a network of structural proteins, including laminin (LM) and fibronectin (FN), that provide mechanical support while acting as physical barrier against intestinal pathogens. Here, we employed ELISA and immunofluo"],"journal":["International journal of molecular sciences"],"pubmed_title":["Molecular Characterization of the Interplay between <i>Fasciola hepatica</i> Juveniles and Laminin as a Mechanism to Adhere to and Break through the Host Intestinal Wall."],"pmcid":["PMC10179147"],"funding_grant_id":["Programme for strengthening research structures \"Stairway to excellence\" internationalisation aid","PT17/0019","PID2019-108782RB-C22","RTI2018-093463-J-100","FPU Predoctoral contract of M.L.G.","RYC2020-030575-I","CLU-2019-05 - IRNASA-CSIC Unit of Excellence","Predoctoral contracts of J.S. and D.B.R."],"pubmed_authors":["Siles-Lucas M","Lopez-Garcia M","Becerro-Recio D","Torres-Valle M","Serrat J","Gonzalez-Miguel J"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Characterization of the Interplay between <i>Fasciola hepatica</i> Juveniles and Laminin as a Mechanism to Adhere to and Break through the Host Intestinal Wall.","description":"<i>Fasciola hepatica</i> is the main causative agent of fasciolosis, a zoonotic parasitic disease of growing public health concern. <i>F. hepatica</i> metacercariae are ingested by the host and excyst in the intestine, thereby releasing the newly excysted juveniles (FhNEJ), which traverse the gut wall and migrate towards the biliary ducts. Since blocking <i>F. hepatica</i> development is challenging after crossing of the intestinal wall, targeting this first step of migration might result in increased therapeutic success. The intestinal extracellular matrix (ECM) is constituted by a network of structural proteins, including laminin (LM) and fibronectin (FN), that provide mechanical support while acting as physical barrier against intestinal pathogens. Here, we employed ELISA and immunofluo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-04-08T14:00:55.98Z","creation":"2026-04-08T03:24:31.127Z"},"accession":"S-EPMC10179147","cross_references":{"pubmed":["37175870"],"doi":["10.3390/ijms24098165"]}}