{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ceja L"],"funding":["California Institute for Regenerative Medicine"],"pagination":["8088"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(9)"],"pubmed_abstract":["New stem cell and extracellular-vesicle-based therapies have the potential to improve outcomes for the increasing number of patients with heart failure. Since neonates have a significantly enhanced regenerative ability, we hypothesized that extracellular vesicles isolated from Islet-1+ expressing neonatal human cardiovascular progenitors (CPCs) will induce transcriptomic changes associated with improved regenerative capability when co-cultured with CPCs derived from adult humans. In order to test this hypothesis, we isolated extracellular vesicles from human neonatal Islet-1+ CPCs, analyzed the extracellular vesicle content using RNAseq, and treated adult CPCs with extracellular vesicles derived from neonatal CPCs to assess their functional effect. AKT, ERBB, and YAP1 transcripts were elev"],"journal":["International journal of molecular sciences"],"pubmed_title":["Neonatal Cardiovascular-Progenitor-Cell-Derived Extracellular Vesicles Activate YAP1 in Adult Cardiac Progenitor Cells."],"pmcid":["PMC10179407"],"funding_grant_id":["EDUC2-08418"],"pubmed_authors":["Ceja L","Hughes L","Camberos V","Vallejos P","Lopez LV","Wall NR","Kearns-Jonker M","Escopete SS"],"additional_accession":[]},"is_claimable":false,"name":"Neonatal Cardiovascular-Progenitor-Cell-Derived Extracellular Vesicles Activate YAP1 in Adult Cardiac Progenitor Cells.","description":"New stem cell and extracellular-vesicle-based therapies have the potential to improve outcomes for the increasing number of patients with heart failure. Since neonates have a significantly enhanced regenerative ability, we hypothesized that extracellular vesicles isolated from Islet-1+ expressing neonatal human cardiovascular progenitors (CPCs) will induce transcriptomic changes associated with improved regenerative capability when co-cultured with CPCs derived from adult humans. In order to test this hypothesis, we isolated extracellular vesicles from human neonatal Islet-1+ CPCs, analyzed the extracellular vesicle content using RNAseq, and treated adult CPCs with extracellular vesicles derived from neonatal CPCs to assess their functional effect. AKT, ERBB, and YAP1 transcripts were elev","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-21T22:46:00.831Z","creation":"2025-04-05T18:51:41.542Z"},"accession":"S-EPMC10179407","cross_references":{"pubmed":["37175796"],"doi":["10.3390/ijms24098088"]}}