{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(9)"],"submitter":["Kelaidonis K"],"pubmed_abstract":["This study is an extension of current research into a novel class of synthetic antihypertensive drugs referred to as \"bisartans\", which are bis-alkylated imidazole derivatives bearing two symmetric anionic biphenyltetrazoles. Research to date indicates that bisartans are superior to commercially available hypertension drugs, since the former undergo stronger docking to angiotensin-converting enzyme 2 (ACE2). ACE2 is the key receptor involved in SARS-CoV-2 entry, thus initiating COVID-19 infection and in regulating levels of vasoactive peptides such as angiotensin II and beneficial heptapeptides A(1-7) and Alamandine in the renin-angiotensin system (RAS). In previous studies using in vivo rabbit-iliac arterial models, we showed that Na<sup>+</sup> or K<sup>+</sup> salts of selected Bisartan"],"journal":["International journal of molecular sciences"],"pagination":["8454"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179460"],"repository":["biostudies-literature"],"pubmed_title":["Computational and Enzymatic Studies of Sartans in SARS-CoV-2 Spike RBD-ACE2 Binding: The Role of Tetrazole and Perspectives as Antihypertensive and COVID-19 Therapeutics."],"pmcid":["PMC10179460"],"pubmed_authors":["Vassilaki N","Hoffmann W","Mavromoustakos T","Wegrzyn K","Matsoukas JM","Ligielli I","Ridgway H","Letsios S","Chasapis CT","Kelaidonis K","Vidali VP","Moore GJ"],"additional_accession":[]},"is_claimable":false,"name":"Computational and Enzymatic Studies of Sartans in SARS-CoV-2 Spike RBD-ACE2 Binding: The Role of Tetrazole and Perspectives as Antihypertensive and COVID-19 Therapeutics.","description":"This study is an extension of current research into a novel class of synthetic antihypertensive drugs referred to as \"bisartans\", which are bis-alkylated imidazole derivatives bearing two symmetric anionic biphenyltetrazoles. Research to date indicates that bisartans are superior to commercially available hypertension drugs, since the former undergo stronger docking to angiotensin-converting enzyme 2 (ACE2). ACE2 is the key receptor involved in SARS-CoV-2 entry, thus initiating COVID-19 infection and in regulating levels of vasoactive peptides such as angiotensin II and beneficial heptapeptides A(1-7) and Alamandine in the renin-angiotensin system (RAS). In previous studies using in vivo rabbit-iliac arterial models, we showed that Na<sup>+</sup> or K<sup>+</sup> salts of selected Bisartan","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-05T11:57:27.628Z","creation":"2024-11-15T19:25:54.655Z"},"accession":"S-EPMC10179460","cross_references":{"pubmed":["37176159"],"doi":["10.3390/ijms24098454"]}}