biostudies-literatureZhao Jthe Key Project of Zhejiang Provincial Natural Science Foundation of ChinaZhejiang Provincial Natural Science Foundation of ChinaNational Natural Science Foundation of China8115https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179522biostudies-literatureUnknown24(9)Salinity is a major abiotic stress that harms rice growth and productivity. Low phosphate roots (LPRs) play a central role in Pi deficiency-mediated inhibition of primary root growth and have ferroxidase activity. However, the function of LPRs in salt stress response and tolerance in plants remains largely unknown. Here, we reported that the <i>OsLPR5</i> was induced by NaCl stress and positively regulates the tolerance to salt stress in rice. Under NaCl stress, overexpression of <i>OsLPR5</i> led to increased ferroxidase activity, more green leaves, higher levels of chlorophyll and lower MDA contents compared with the WT. In addition, OsLPR5 could promote the accumulation of cell osmotic adjustment substances and promote ROS-scavenging enzyme activities. Conversely, the mutant <i>lpr5</i>International journal of molecular sciences<i>OsLPR5</i> Encoding Ferroxidase Positively Regulates the Tolerance to Salt Stress in Rice.PMC10179522LZ19B070001322016973197295932101658LQ21C130001Wang MZhang ZLiu QNie FZhao JMeng Xfalse<i>OsLPR5</i> Encoding Ferroxidase Positively Regulates the Tolerance to Salt Stress in Rice.Salinity is a major abiotic stress that harms rice growth and productivity. Low phosphate roots (LPRs) play a central role in Pi deficiency-mediated inhibition of primary root growth and have ferroxidase activity. However, the function of LPRs in salt stress response and tolerance in plants remains largely unknown. Here, we reported that the <i>OsLPR5</i> was induced by NaCl stress and positively regulates the tolerance to salt stress in rice. Under NaCl stress, overexpression of <i>OsLPR5</i> led to increased ferroxidase activity, more green leaves, higher levels of chlorophyll and lower MDA contents compared with the WT. In addition, OsLPR5 could promote the accumulation of cell osmotic adjustment substances and promote ROS-scavenging enzyme activities. Conversely, the mutant <i>lpr5</i>2023-01-01T00:00:00Z2023 Apr2025-04-05T09:12:33.615Z2025-04-05T09:12:33.615ZS-EPMC101795223717582210.3390/ijms24098115