{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim Y"],"funding":["Ministry of SMEs and Startups"],"pagination":["3814"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(9)"],"pubmed_abstract":["The pharmacological potential of industrial hemp (<i>Cannabis sativa</i>) has been widely studied. However, the majority of studies have focused on cannabidiol, isolated from the inflorescence and leaf of the plant. In the present study, we evaluated the anti-diabetic potential of hemp root water (HWE) and ethanol extracts (HEE) in streptozotocin (STZ)-induced insulin-deficient diabetic mice. The administration of HWE and HEE ameliorated hyperglycemia and improved glucose homeostasis and islet function in STZ-treated mice (<i>p</i> < 0.05). HWE and HEE suppressed β-cell apoptosis and cytokine-induced inflammatory signaling in the pancreas (<i>p</i> < 0.05). Moreover, HWE and HEE normalized insulin-signaling defects in skeletal muscles and apoptotic response in the liver and kidney induced by STZ (<i>p</i> < 0.05). Gas chromatography-mass spectrometry analysis of HWE and HEE showed possible active compounds which might be responsible for the observed anti-diabetic potential. These findings indicate the possible mechanisms by which hemp root extracts protect mice against insulin-deficient diabetes, and support the need for further studies geared towards the application of hemp root as a novel bioactive material."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Protective Effects of Hemp (<i>Cannabis sativa</i>) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice."],"pmcid":["PMC10179809"],"funding_grant_id":["P0016082"],"pubmed_authors":["Lee JB","Cho KH","Kim SH","Kwon GS","Kim W","Kim Y","Sim KS","Kim JH","Kim KH"],"additional_accession":[]},"is_claimable":false,"name":"Protective Effects of Hemp (<i>Cannabis sativa</i>) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice.","description":"The pharmacological potential of industrial hemp (<i>Cannabis sativa</i>) has been widely studied. However, the majority of studies have focused on cannabidiol, isolated from the inflorescence and leaf of the plant. In the present study, we evaluated the anti-diabetic potential of hemp root water (HWE) and ethanol extracts (HEE) in streptozotocin (STZ)-induced insulin-deficient diabetic mice. The administration of HWE and HEE ameliorated hyperglycemia and improved glucose homeostasis and islet function in STZ-treated mice (<i>p</i> < 0.05). HWE and HEE suppressed β-cell apoptosis and cytokine-induced inflammatory signaling in the pancreas (<i>p</i> < 0.05). Moreover, HWE and HEE normalized insulin-signaling defects in skeletal muscles and apoptotic response in the liver and kidney induced by STZ (<i>p</i> < 0.05). Gas chromatography-mass spectrometry analysis of HWE and HEE showed possible active compounds which might be responsible for the observed anti-diabetic potential. These findings indicate the possible mechanisms by which hemp root extracts protect mice against insulin-deficient diabetes, and support the need for further studies geared towards the application of hemp root as a novel bioactive material.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-21T22:44:28.988Z","creation":"2025-04-05T18:50:53.816Z"},"accession":"S-EPMC10179809","cross_references":{"pubmed":["37175224"],"doi":["10.3390/molecules28093814"]}}