{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang X"],"funding":["First-class discipline of Traditional Chinese Pharmacology of Jiangxi Province","iangxi Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Vascu-lar Remodeling Related Diseases","the National Natural Science Foundation of China"],"pagination":["3682"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(9)"],"pubmed_abstract":["<i>Pulsatilla saponins</i> (PS) extracts from Pulsatilla chinensis (Bge.) Regel, are a commonly used traditional Chinese medicine. In the previous study, we found <i>Pulsatilla saponins</i> displayed anti-tumor activity without side effects such as bone marrow suppression. However, the mechanism of the anti-tumor effect was not illustrated well. Since M2-like tumor-associated macrophages (TAMs) that required activation of the signal transducer and activator of transcription 6 (STAT6) for polarization are the important immune cells in the tumor microenvironment and play a key role in tumor progress and metastasis, this study aimed to confirm whether <i>Pulsatilla saponins</i> could inhibit the development and metastasis of tumors by inhibiting the polarization of M2 macrophages. We investig"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Pulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization."],"pmcid":["PMC10179893"],"funding_grant_id":["81660683","JXSYLXK-ZHYAO107","JXSYLXK-ZHYAO014","82060735","20202BCD42014","JXSYLXK-ZHYAO021","JXSYLXK-ZHYAO122"],"pubmed_authors":["Yang X","Wu M","Luo Y","Zhang C","Yu J","Yan X"],"additional_accession":[]},"is_claimable":false,"name":"Pulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization.","description":"<i>Pulsatilla saponins</i> (PS) extracts from Pulsatilla chinensis (Bge.) Regel, are a commonly used traditional Chinese medicine. In the previous study, we found <i>Pulsatilla saponins</i> displayed anti-tumor activity without side effects such as bone marrow suppression. However, the mechanism of the anti-tumor effect was not illustrated well. Since M2-like tumor-associated macrophages (TAMs) that required activation of the signal transducer and activator of transcription 6 (STAT6) for polarization are the important immune cells in the tumor microenvironment and play a key role in tumor progress and metastasis, this study aimed to confirm whether <i>Pulsatilla saponins</i> could inhibit the development and metastasis of tumors by inhibiting the polarization of M2 macrophages. We investig","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-26T14:27:19.123Z","creation":"2025-04-06T14:36:43.947Z"},"accession":"S-EPMC10179893","cross_references":{"pubmed":["37175092"],"doi":["10.3390/molecules28093682"]}}