biostudies-literatureYang XFirst-class discipline of Traditional Chinese Pharmacology of Jiangxi Provinceiangxi Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Vascu-lar Remodeling Related Diseasesthe National Natural Science Foundation of China3682https://www.ebi.ac.uk/biostudies/studies/S-EPMC10179893biostudies-literatureUnknown28(9)<i>Pulsatilla saponins</i> (PS) extracts from Pulsatilla chinensis (Bge.) Regel, are a commonly used traditional Chinese medicine. In the previous study, we found <i>Pulsatilla saponins</i> displayed anti-tumor activity without side effects such as bone marrow suppression. However, the mechanism of the anti-tumor effect was not illustrated well. Since M2-like tumor-associated macrophages (TAMs) that required activation of the signal transducer and activator of transcription 6 (STAT6) for polarization are the important immune cells in the tumor microenvironment and play a key role in tumor progress and metastasis, this study aimed to confirm whether <i>Pulsatilla saponins</i> could inhibit the development and metastasis of tumors by inhibiting the polarization of M2 macrophages. We investigMolecules (Basel, Switzerland)Pulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization.PMC1017989381660683JXSYLXK-ZHYAO107JXSYLXK-ZHYAO0148206073520202BCD42014JXSYLXK-ZHYAO021JXSYLXK-ZHYAO122Yang XWu MLuo YZhang CYu JYan XfalsePulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization.<i>Pulsatilla saponins</i> (PS) extracts from Pulsatilla chinensis (Bge.) Regel, are a commonly used traditional Chinese medicine. In the previous study, we found <i>Pulsatilla saponins</i> displayed anti-tumor activity without side effects such as bone marrow suppression. However, the mechanism of the anti-tumor effect was not illustrated well. Since M2-like tumor-associated macrophages (TAMs) that required activation of the signal transducer and activator of transcription 6 (STAT6) for polarization are the important immune cells in the tumor microenvironment and play a key role in tumor progress and metastasis, this study aimed to confirm whether <i>Pulsatilla saponins</i> could inhibit the development and metastasis of tumors by inhibiting the polarization of M2 macrophages. We investig2023-01-01T00:00:00Z2023 Apr2025-04-26T14:27:19.123Z2025-04-06T14:36:43.947ZS-EPMC101798933717509210.3390/molecules28093682