biostudies-literatureRooney AGMedical Research FoundationBrain Tumour CharityMedical Research CouncilMRF_The Brain Tumour Charity249-260https://www.ebi.ac.uk/biostudies/studies/S-EPMC10180387biostudies-literatureUnknown10(3)<h4>Background</h4>There are no effective treatments for brain tumor-related fatigue. We studied the feasibility of two novel lifestyle coaching interventions in fatigued brain tumor patients.<h4>Methods</h4>This phase I/feasibility multi-center RCT recruited patients with a clinically stable primary brain tumor and significant fatigue (mean Brief Fatigue Inventory [BFI] score ≥ 4/10). Participants were randomized in a 1-1-1 allocation ratio to: Control (usual care); Health Coaching ("HC", an eight-week program targeting lifestyle behaviors); or HC plus Activation Coaching ("HC + AC", further targeting self-efficacy). The primary outcome was feasibility of recruitment and retention. Secondary outcomes were intervention acceptability, which was evaluated via qualitative interview, and safetNeuro-oncology practiceLifestyle coaching is feasible in fatigued brain tumor patients: A phase I/feasibility, multi-center, mixed-methods randomized controlled trial.PMC10180387GN000436MR/J000914/1C0396GN-000436Grant RHill RCarruthers JDay JRooney AGClark ABulbeck HMackinnon MWells MWalker AGillespie DChalmers AJHewins WDunlop JEmerson JWithington LHewitt CHopcroft LEMCochrane CDyson AMcBain CRobson STorrens CAnderson GWelsh MMolinari EfalseLifestyle coaching is feasible in fatigued brain tumor patients: A phase I/feasibility, multi-center, mixed-methods randomized controlled trial.<h4>Background</h4>There are no effective treatments for brain tumor-related fatigue. We studied the feasibility of two novel lifestyle coaching interventions in fatigued brain tumor patients.<h4>Methods</h4>This phase I/feasibility multi-center RCT recruited patients with a clinically stable primary brain tumor and significant fatigue (mean Brief Fatigue Inventory [BFI] score ≥ 4/10). Participants were randomized in a 1-1-1 allocation ratio to: Control (usual care); Health Coaching ("HC", an eight-week program targeting lifestyle behaviors); or HC plus Activation Coaching ("HC + AC", further targeting self-efficacy). The primary outcome was feasibility of recruitment and retention. Secondary outcomes were intervention acceptability, which was evaluated via qualitative interview, and safet2023-01-01T00:00:00Z2023 Jun2026-07-14T17:01:07.48Z2025-04-05T09:11:35.449ZS-EPMC101803873718816310.1093/nop/npac086