biostudies-literatureUnknown9(19)Haueise TThis research addresses the assessment of adipose tissue (AT) and spatial distribution of visceral (VAT) and subcutaneous fat (SAT) in the trunk from standardized magnetic resonance imaging at 3 T, thereby demonstrating the feasibility of deep learning (DL)-based image segmentation in a large population-based cohort in Germany (five sites). Volume and distribution of AT play an essential role in the pathogenesis of insulin resistance, a risk factor of developing metabolic/cardiovascular diseases. Cross-validated training of the DL-segmentation model led to a mean Dice similarity coefficient of >0.94, corresponding to a mean absolute volume deviation of about 22 ml. SAT is significantly increased in women compared to men, whereas VAT is increased in males. Spatial distribution shows age- anScience advanceseadd0433https://www.ebi.ac.uk/biostudies/studies/S-EPMC10181183biostudies-literatureAnalysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort.PMC10181183Machann JPeters ANorajitra TJockel KHGobel-Gueniot KVolzke HStefan NHaueise TSchick FHosten NWillich SNSchlett CLUmutlu LKroncke TWeiss JBKauczor HUBamberg FMaier-Hein KHRospleszcz SKrist LNonnenmacher TPischon TNattenmuller JNiendorf TfalseAnalysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort.This research addresses the assessment of adipose tissue (AT) and spatial distribution of visceral (VAT) and subcutaneous fat (SAT) in the trunk from standardized magnetic resonance imaging at 3 T, thereby demonstrating the feasibility of deep learning (DL)-based image segmentation in a large population-based cohort in Germany (five sites). Volume and distribution of AT play an essential role in the pathogenesis of insulin resistance, a risk factor of developing metabolic/cardiovascular diseases. Cross-validated training of the DL-segmentation model led to a mean Dice similarity coefficient of >0.94, corresponding to a mean absolute volume deviation of about 22 ml. SAT is significantly increased in women compared to men, whereas VAT is increased in males. Spatial distribution shows age- an2023-01-01T00:00:00Z2023 May2025-04-21T22:44:14.392Z2025-04-05T18:50:46.051ZS-EPMC101811833717209310.1126/sciadv.add0433