biostudies-literatureUnknown29(8)Bornemann L<h4>Objectives</h4>Antigen rapid diagnostic tests (Ag-RDTs) play an important role in the diagnosis of SARS-CoV-2. They are easier, quicker, and less expensive than the 'reference standard' RT-PCR and therefore widely in use. Reliable clinical data with respect to Ag-RDT performance in SARS-CoV-2 Omicron variants of concern (VOCs) are limited. Consequently, the objective of this study was to determine the impact different VOCs-especially Omicron-have on the clinical performance of an Ag-RDT.<h4>Methods</h4>We compared the clinical performance of the Sofia SARS-CoV-2 Ag-RDT to RT-PCR in a real-world, single-centre study in a clinical point-of-care setting in patients admitted to a large hospital via the emergency department from 2 November 2020 to 4 September 2022.<h4>Results</h4>Among 38 4Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases1085.e1-1085.e8https://www.ebi.ac.uk/biostudies/studies/S-EPMC10181871biostudies-literatureVirus variant-specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on Omicron variants of concern.PMC10181871Hoyer ABornemann LKleideiter JRuprecht BWehmeier MKaup OBornemann RPanning MfalseVirus variant-specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on Omicron variants of concern.<h4>Objectives</h4>Antigen rapid diagnostic tests (Ag-RDTs) play an important role in the diagnosis of SARS-CoV-2. They are easier, quicker, and less expensive than the 'reference standard' RT-PCR and therefore widely in use. Reliable clinical data with respect to Ag-RDT performance in SARS-CoV-2 Omicron variants of concern (VOCs) are limited. Consequently, the objective of this study was to determine the impact different VOCs-especially Omicron-have on the clinical performance of an Ag-RDT.<h4>Methods</h4>We compared the clinical performance of the Sofia SARS-CoV-2 Ag-RDT to RT-PCR in a real-world, single-centre study in a clinical point-of-care setting in patients admitted to a large hospital via the emergency department from 2 November 2020 to 4 September 2022.<h4>Results</h4>Among 38 42023-01-01T00:00:00Z2023 Aug2025-06-28T03:05:14.899Z2024-12-04T08:12:04.405ZS-EPMC101818713718263910.1016/j.cmi.2023.05.009