biostudies-literatureMiyakawa RIntelligent Cosmos Academic FoundationSeiichi Imai Memorial FoundationJapan Society for the Promotion of Science95https://www.ebi.ac.uk/biostudies/studies/S-EPMC10182672biostudies-literatureUnknown16(1)<h4>Background</h4>Ovarian cancer has the worst outcome among gynecological malignancies; therefore, biomarkers that could contribute to the early diagnosis and/or prognosis prediction are urgently required. In the present study, we focused on the secreted protein spondin-1 (SPON1) and clarified the prognostic relevance in ovarian cancer.<h4>Methods</h4>We developed a monoclonal antibody (mAb) that selectively recognizes SPON1. Using this specific mAb, we determined the expression of SPON1 protein in the normal ovary, serous tubal intraepithelial carcinoma (STIC), and ovarian cancer tissues, as well as in various normal adult tissues by immunohistochemistry, and verified its clinicopathological significance in ovarian cancer.<h4>Results</h4>The normal ovarian tissue was barely positive forJournal of ovarian researchSPON1 is an independent prognostic biomarker for ovarian cancer.PMC1018267221K15386Watanabe TChiba HFujimori KKobayashi MKojima MMiyakawa RHashimoto YSoeda SEndo YKobayashi YFurukawa SSugimoto KHonda TAsano SfalseSPON1 is an independent prognostic biomarker for ovarian cancer.<h4>Background</h4>Ovarian cancer has the worst outcome among gynecological malignancies; therefore, biomarkers that could contribute to the early diagnosis and/or prognosis prediction are urgently required. In the present study, we focused on the secreted protein spondin-1 (SPON1) and clarified the prognostic relevance in ovarian cancer.<h4>Methods</h4>We developed a monoclonal antibody (mAb) that selectively recognizes SPON1. Using this specific mAb, we determined the expression of SPON1 protein in the normal ovary, serous tubal intraepithelial carcinoma (STIC), and ovarian cancer tissues, as well as in various normal adult tissues by immunohistochemistry, and verified its clinicopathological significance in ovarian cancer.<h4>Results</h4>The normal ovarian tissue was barely positive for2023-01-01T00:00:00Z2023 May2025-04-22T14:39:16.929Z2025-04-06T01:07:45.913ZS-EPMC101826723717935510.1186/s13048-023-01180-8