{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Namkung H"],"funding":["National Alliance for Research on Schizophrenia and Depression","NIMH NIH HHS","Brain and Behavior Research Foundation","National Institute of Mental Health"],"pagination":["220-235.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10183200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(2)"],"pubmed_abstract":["Schizophrenia (SZ) and bipolar disorder (BP) are highly heritable major psychiatric disorders that share a substantial portion of genetic risk as well as their clinical manifestations. This raises a fundamental question of whether, and how, common neurobiological pathways translate their shared polygenic risks into shared clinical manifestations. This study shows the miR-124-3p-AMPAR pathway as a key common neurobiological mediator that connects polygenic risks with behavioral changes shared between these two psychotic disorders. We discovered the upregulation of miR-124-3p in neuronal cells and the postmortem prefrontal cortex from both SZ and BP patients. Intriguingly, the upregulation is associated with the polygenic risks shared between these two disorders. Seeking mechanistic dissecti"],"journal":["Neuron"],"pubmed_title":["The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder."],"pmcid":["PMC10183200"],"funding_grant_id":["MH-107730","R01 MH092443","MH-105660","P50 MH094268","R01 MH105660","MH-092443","MH-094268","R01 MH107730","RUSK/S-R"],"pubmed_authors":["Jaaro-Peled H","Tian M","Fukudome D","Chatterjee N","Namkung H","Zandi P","Sawa A","Niwa M","Sharma K","Ishizuka K","Lee BJ","Srivastava R","Kannan S","Ursini G","Lam S","Saito A","Yukitake H","Huganir RL"],"additional_accession":[]},"is_claimable":false,"name":"The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder.","description":"Schizophrenia (SZ) and bipolar disorder (BP) are highly heritable major psychiatric disorders that share a substantial portion of genetic risk as well as their clinical manifestations. This raises a fundamental question of whether, and how, common neurobiological pathways translate their shared polygenic risks into shared clinical manifestations. This study shows the miR-124-3p-AMPAR pathway as a key common neurobiological mediator that connects polygenic risks with behavioral changes shared between these two psychotic disorders. We discovered the upregulation of miR-124-3p in neuronal cells and the postmortem prefrontal cortex from both SZ and BP patients. Intriguingly, the upregulation is associated with the polygenic risks shared between these two disorders. Seeking mechanistic dissecti","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T21:53:23.863Z","creation":"2024-11-14T18:04:41.835Z"},"accession":"S-EPMC10183200","cross_references":{"pubmed":["36379214"],"doi":["10.1016/j.neuron.2022.10.031"]}}