biostudies-literaturePolcz MNCI NIH HHS2795-2803https://www.ebi.ac.uk/biostudies/studies/S-EPMC10184500biostudies-literatureUnknown27(8)<h4>Background</h4>Approximately 35% of patients with midgut neuroendocrine tumors (MNET) present with distant metastases. Although successful resection of these metastatic foci improves overall survival (OS), the role of primary tumor resection (PTR) in patients with unresectable metastatic disease is unclear. The aim of this study is to evaluate prevalence and survival impact of PTR in patients with unresectable metastatic MNET.<h4>Patients and methods</h4>A retrospective cohort study of patients with metastatic MNET was performed using the National Cancer Database (2004-2014). Demographic and clinicopathologic variables were compared between patients who did and did not undergo PTR. Survival analysis was performed using Kaplan-Meier and log-rank tests. Multivariable regression analysis Annals of surgical oncologyPrimary Tumor Resection Offers Survival Benefit in Patients with Metastatic Midgut Neuroendocrine Tumors.PMC10184500K12 CA090625Kiernan CTan MSchlegel CEdwards GCWang FSolorzano CCParikh AIdrees KBailey CEPolcz MfalsePrimary Tumor Resection Offers Survival Benefit in Patients with Metastatic Midgut Neuroendocrine Tumors.<h4>Background</h4>Approximately 35% of patients with midgut neuroendocrine tumors (MNET) present with distant metastases. Although successful resection of these metastatic foci improves overall survival (OS), the role of primary tumor resection (PTR) in patients with unresectable metastatic disease is unclear. The aim of this study is to evaluate prevalence and survival impact of PTR in patients with unresectable metastatic MNET.<h4>Patients and methods</h4>A retrospective cohort study of patients with metastatic MNET was performed using the National Cancer Database (2004-2014). Demographic and clinicopathologic variables were compared between patients who did and did not undergo PTR. Survival analysis was performed using Kaplan-Meier and log-rank tests. Multivariable regression analysis 2020-01-01T00:00:00Z2020 Aug2025-04-05T10:55:20.757Z2025-04-05T10:55:20.757ZS-EPMC101845003243075210.1245/s10434-020-08602-7