{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Insco ML"],"funding":["NCI NIH HHS"],"pagination":["eabn7625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10184553"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["380(6642)"],"pubmed_abstract":["RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 (<i>CDK13</i>) is mutated in melanoma, and patient-mutated <i>CDK13</i> accelerates zebrafish melanoma. <i>CDK13</i> mutation causes aberrant RNA stabilization. CDK13 is required for ZC3H14 phosphorylation, which is necessary and sufficient to promote nuclear RNA degradation. Mutant CDK13 fails to activate nuclear RNA surveillance, causing aberrant protein-coding transcripts to be stabilized and translated. Forced aberrant RNA expression accelerates melanoma in zebrafish. We found recurrent mutations in genes encoding nuclear RNA surveillance components in many malignancies, establishing nuclear RNA surveillance"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Oncogenic <i>CDK13</i> mutations impede nuclear RNA surveillance."],"pmcid":["PMC10184553"],"funding_grant_id":["R01 CA103846"],"pubmed_authors":["Insco ML","Cox AM","Wu C","Boutz PL","Sharp PA","Martin BJE","Brown KM","Kaltheuner IH","Young RA","Geyer M","Chen KY","Ludwig CG","Abraham BJ","Chanock SJ","Fabo T","Zon LI","Dubbury SJ","Zhang T","Dust S","Henriques T","Liu D","Bellaousov S","Esgdaille DE","Modhurima R","Adelman K"],"additional_accession":[]},"is_claimable":false,"name":"Oncogenic <i>CDK13</i> mutations impede nuclear RNA surveillance.","description":"RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 (<i>CDK13</i>) is mutated in melanoma, and patient-mutated <i>CDK13</i> accelerates zebrafish melanoma. <i>CDK13</i> mutation causes aberrant RNA stabilization. CDK13 is required for ZC3H14 phosphorylation, which is necessary and sufficient to promote nuclear RNA degradation. Mutant CDK13 fails to activate nuclear RNA surveillance, causing aberrant protein-coding transcripts to be stabilized and translated. Forced aberrant RNA expression accelerates melanoma in zebrafish. We found recurrent mutations in genes encoding nuclear RNA surveillance components in many malignancies, establishing nuclear RNA surveillance","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-21T22:37:46.483Z","creation":"2025-04-05T18:51:40.223Z"},"accession":"S-EPMC10184553","cross_references":{"pubmed":["37079685"],"doi":["10.1126/science.abn7625"]}}