{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen X"],"funding":["National Natural Science Foundation of China"],"pagination":["2208707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10184595"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Glutathione peroxidase 8 (GPX8) is a key regulator of redox homoeostasis. Whether its antioxidant activity participates in the regulation of m<sup>6</sup>A modification is a crucial issue, which has important application value in cancer treatment. In this study, MeRIP-seq was used to explore the characteristics of transcriptome-wide m<sup>6</sup>A modification in GPX8-deficient oral cancer cells. Oxidative stress caused by the lack of GPX8 resulted in 1,279 hyper- and 2,287 hypo-methylated m<sup>6</sup>A peaks and 2,036 differentially expressed genes in GPX8-KO cells. Twenty-eight differentially expressed genes were related to the cell response to oxidative stress, and half of them changed their m<sup>6</sup>A modification. In GPX8-KO cells, m<sup>6</sup>A regulators IGF2BP2 and IGF2BP3 we"],"journal":["Epigenetics"],"pubmed_title":["GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells."],"pmcid":["PMC10184595"],"funding_grant_id":["81873711"],"pubmed_authors":["Wu J","He Y","Wang C","Chen L","Yuan L","Zhao W","Yu D","Chen X","Zhang L","Chen S"],"additional_accession":[]},"is_claimable":false,"name":"GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells.","description":"Glutathione peroxidase 8 (GPX8) is a key regulator of redox homoeostasis. Whether its antioxidant activity participates in the regulation of m<sup>6</sup>A modification is a crucial issue, which has important application value in cancer treatment. In this study, MeRIP-seq was used to explore the characteristics of transcriptome-wide m<sup>6</sup>A modification in GPX8-deficient oral cancer cells. Oxidative stress caused by the lack of GPX8 resulted in 1,279 hyper- and 2,287 hypo-methylated m<sup>6</sup>A peaks and 2,036 differentially expressed genes in GPX8-KO cells. Twenty-eight differentially expressed genes were related to the cell response to oxidative stress, and half of them changed their m<sup>6</sup>A modification. In GPX8-KO cells, m<sup>6</sup>A regulators IGF2BP2 and IGF2BP3 we","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-25T22:33:29.563Z","creation":"2025-04-06T09:03:59.741Z"},"accession":"S-EPMC10184595","cross_references":{"pubmed":["37170591"],"doi":["10.1080/15592294.2023.2208707"]}}