{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilder AP"],"funding":["European Research Council","Howard Hughes Medical Institute","NHGRI NIH HHS","NCI NIH HHS"],"pagination":["eabn5856"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10184782"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["380(6643)"],"pubmed_abstract":["Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic variation across single genomes of 240 mammals that compose the Zoonomia alignment to evaluate how historical effective population size (<i>N</i><sub>e</sub>) affects heterozygosity and deleterious genetic load and how these factors may contribute to extinction risk. We find that species with smaller historical <i>N</i><sub>e</sub> carry a proportionally larger burden of deleterious alleles owing to long-term accumulation and fixation of genetic load and have a higher risk of extinction. This suggests that historical demography can inform contemporary resilience. Model"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["The contribution of historical processes to contemporary extinction risk in placental mammals."],"pmcid":["PMC10184782"],"funding_grant_id":["R01 HG008742","R01 CA092039","P01 CA095616","R01 HG010485","864203"],"pubmed_authors":["Talbot JE","Valenzuela A","Goodman L","Eizirik E","Hubley RM","Lehmann T","Garcia CJ","Swofford R","Moore JE","Juan D","Gazal S","Gatesy J","Kaplow IM","Kozyrev SV","Osmanski A","Sullivan PF","Sullivan KAM","Lawler AJ","Munoz Fuentes V","Shapiro B","Marques-Bonet T","Ray DA","Christmas MJ","Genereux DP","Mason VC","Pfenning AR","Keough KC","Lewin HA","Ryder OA","Moreno-Santillan DD","Steiner C","Springer M","Turner-Maier J","Xue JR","Andrews G","Pollard KS","Diekhans M","Hiller M","Meadows JRS","Serres A","Fan K","Hickey G","Dong MX","Di Palma F","Levesque DL","Bredemeyer KR","Reilly SK","Birren BW","Ruf I","Zoonomia Consortium‡","Pratt HE","Sabeti PC","Foley K","Moreira LR","Paten B","Breit AM","Wang C","Hughes GM","Subramanian A","Armstrong JC","Wang J","Lindblad-Toh K","Foley NM","Sundstrom E","Damas J","Weng Z","Halsey MK","Wirthlin ME","Mudide A","Clawson H","Wagner F","Wallerman O","Storer JM","Paulat NS","Li X","Karlsson EK","Marinescu VD","Schaffer DE","Nweeia M","Grimshaw J","Hindle AG","Forsberg-Nilsson K","Koepfli KP","Johnson J","Mackay-Smith A","Serres-Armero A","Ryan L","Lawless C","Supple MA","Meyer WK","Muntane G","Ortmann S","Rosen JR","Korstian JM","Lind A","Navarro A","Morrill KM","Smit AFA","Fanter C","Bianchi M","Teeling E","Kirilenko B","Murphy WJ","Srinivasan C","Kowalczyk A","Phan BN","Zhang X","Harris AJ","Wilder AP"],"additional_accession":[]},"is_claimable":false,"name":"The contribution of historical processes to contemporary extinction risk in placental mammals.","description":"Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic variation across single genomes of 240 mammals that compose the Zoonomia alignment to evaluate how historical effective population size (<i>N</i><sub>e</sub>) affects heterozygosity and deleterious genetic load and how these factors may contribute to extinction risk. We find that species with smaller historical <i>N</i><sub>e</sub> carry a proportionally larger burden of deleterious alleles owing to long-term accumulation and fixation of genetic load and have a higher risk of extinction. This suggests that historical demography can inform contemporary resilience. Model","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-28T08:25:03.43Z","creation":"2025-04-05T09:11:30.169Z"},"accession":"S-EPMC10184782","cross_references":{"pubmed":["37104572"],"doi":["10.1126/science.abn5856"]}}