biostudies-literatureUnknownKrupp SNIA NIH HHSAccumulation of cytoplasmic inclusions of TAR-DNA binding protein 43 (TDP-43) is seen in both neurons and glia in a range of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer's disease (AD). Disease progression involves non-cell autonomous interactions among multiple cell types, including neurons, microglia and astrocytes. We investigated the effects in <i>Drosophila</i> of inducible, glial cell type-specific TDP-43 overexpression, a model that causes TDP-43 protein pathology including loss of nuclear TDP-43 and accumulation of cytoplasmic inclusions. We report that TDP-43 pathology in <i>Drosophila</i> is sufficient to cause progressive loss of each of the 5 glial sub-types. But the effects on organismal survival were mbioRxiv : the preprint server for biology2023.05.04.539439https://www.ebi.ac.uk/biostudies/studies/S-EPMC10187300biostudies-literatureTDP-43 pathology in <i>Drosophila</i> induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.PMC10187300RF1 AG076493R01 AG078788RF1 AG057338Krupp STam OHammell MGDubnau JfalseTDP-43 pathology in <i>Drosophila</i> induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.Accumulation of cytoplasmic inclusions of TAR-DNA binding protein 43 (TDP-43) is seen in both neurons and glia in a range of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer's disease (AD). Disease progression involves non-cell autonomous interactions among multiple cell types, including neurons, microglia and astrocytes. We investigated the effects in <i>Drosophila</i> of inducible, glial cell type-specific TDP-43 overexpression, a model that causes TDP-43 protein pathology including loss of nuclear TDP-43 and accumulation of cytoplasmic inclusions. We report that TDP-43 pathology in <i>Drosophila</i> is sufficient to cause progressive loss of each of the 5 glial sub-types. But the effects on organismal survival were m2023-01-01T00:00:00Z2023 May2025-06-25T03:04:20.439Z2025-06-25T03:04:20.439ZS-EPMC101873003720537210.1101/2023.05.04.539439