{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Oliveira CM"],"funding":["Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul","Hospital de Clínicas de Porto Alegre","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior"],"pagination":["4276-4287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10187509"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["270(9)"],"pubmed_abstract":["Background
The natural history of magnetic resonance imaging (MRI) in pre-ataxic stages of spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is not well known. We report cross-sectional and longitudinal data obtained at this stage.Methods
Baseline (follow-up) observations included 32 (17) pre-ataxic carriers (SARA < 3) and 20 (12) related controls. The mutation length was used to estimate the time to onset (TimeTo) of gait ataxia. Clinical scales and MRIs were performed at baseline and after a median (IQR) of 30 (7) months. Cerebellar volumetries (ACAPULCO), deep gray-matter (T1-Multiatlas), cortical thickness (FreeSurfer), cervical spinal cord area (SCT) and white matter (DTI-Multiatlas) were assessed. Baseline differences between groups were described; varia"],"journal":["Journal of neurology"],"pubmed_title":["The longitudinal progression of MRI changes in pre-ataxic carriers of SCA3/MJD."],"pmcid":["PMC10187509"],"funding_grant_id":["17-0201","17-0014","17/2551-0001 1463-4","17-0015","17/2551-0001 035-3","99999.008137/2015-03"],"pubmed_authors":["Anes M","Cappelli AH","Polita S","de Oliveira CM","Duarte JA","Junior MCF","Saraiva-Pereira ML","Rocha AG","Ecco G","Rezende TJR","Kersting N","Jardim LB","Leotti VB","Bolzan G"],"additional_accession":[]},"is_claimable":false,"name":"The longitudinal progression of MRI changes in pre-ataxic carriers of SCA3/MJD.","description":"Background
The natural history of magnetic resonance imaging (MRI) in pre-ataxic stages of spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is not well known. We report cross-sectional and longitudinal data obtained at this stage.Methods
Baseline (follow-up) observations included 32 (17) pre-ataxic carriers (SARA < 3) and 20 (12) related controls. The mutation length was used to estimate the time to onset (TimeTo) of gait ataxia. Clinical scales and MRIs were performed at baseline and after a median (IQR) of 30 (7) months. Cerebellar volumetries (ACAPULCO), deep gray-matter (T1-Multiatlas), cortical thickness (FreeSurfer), cervical spinal cord area (SCT) and white matter (DTI-Multiatlas) were assessed. Baseline differences between groups were described; varia","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-05-28T08:24:50.29Z","creation":"2025-04-05T21:10:27.966Z"},"accession":"S-EPMC10187509","cross_references":{"pubmed":["37193796"],"doi":["10.1007/s00415-023-11763-6"]}}