{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sanchez AM"],"funding":["NSF","NCI NIH HHS","National Institutes of Health","NIH","NIGMS NIH HHS","National Science Foundation"],"pagination":["808-825"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10187668"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(6)"],"pubmed_abstract":["Fission yeast phosphate homeostasis gene <i>pho1</i> is actively repressed during growth in phosphate-rich medium by transcription in <i>cis</i> of a long noncoding (lnc) RNA from the 5' flanking <i>prt(nc-pho1)</i> gene. Pho1 expression is: (i) derepressed by genetic maneuvers that favor precocious lncRNA 3'-processing and termination, in response to DSR and PAS signals in <i>prt</i>; and (ii) hyperrepressed in genetic backgrounds that dampen 3'-processing/termination efficiency. Governors of 3'-processing/termination include the RNA polymerase CTD code, the CPF (cleavage and polyadenylation factor) complex, termination factors Seb1 and Rhn1, and the inositol pyrophosphate signaling molecule 1,5-IP<sub>8</sub> Here, we present genetic and biochemical evidence that fission yeast Duf89, a m"],"journal":["RNA (New York, N.Y.)"],"pubmed_title":["Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination."],"pmcid":["PMC10187668"],"funding_grant_id":["R35 GM126945","P30 CA008748","R35-GM126945","R01-GM134021","1746057","R01 GM134021"],"pubmed_authors":["Schwer B","Shuman S","Garg A","Sanchez AM"],"additional_accession":[]},"is_claimable":false,"name":"Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.","description":"Fission yeast phosphate homeostasis gene <i>pho1</i> is actively repressed during growth in phosphate-rich medium by transcription in <i>cis</i> of a long noncoding (lnc) RNA from the 5' flanking <i>prt(nc-pho1)</i> gene. Pho1 expression is: (i) derepressed by genetic maneuvers that favor precocious lncRNA 3'-processing and termination, in response to DSR and PAS signals in <i>prt</i>; and (ii) hyperrepressed in genetic backgrounds that dampen 3'-processing/termination efficiency. Governors of 3'-processing/termination include the RNA polymerase CTD code, the CPF (cleavage and polyadenylation factor) complex, termination factors Seb1 and Rhn1, and the inositol pyrophosphate signaling molecule 1,5-IP<sub>8</sub> Here, we present genetic and biochemical evidence that fission yeast Duf89, a m","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-07-15T14:55:49.555Z","creation":"2026-07-06T03:09:21.443Z"},"accession":"S-EPMC10187668","cross_references":{"pubmed":["36882296"],"doi":["10.1261/rna.079595.123"]}}