{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wada S"],"funding":["Japan Agency for Medical Research and Development"],"pagination":["494-501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10189082"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(5)"],"pubmed_abstract":["<h4>Background</h4>To examine the utility of fractional flow reserve by coronary computed tomography (CT) angiography (FFR<sub>CT</sub> ) for predicting major adverse cardiovascular events (MACE) in patients with suspected coronary artery disease (CAD).<h4>Methods</h4>This was a nationwide multicenter prospective cohort study including consecutive 1187 patients aged 50-74 years with suspected CAD and had available coronary CT angiography (CCTA). In patients with ≥50% coronary artery stenosis (CAS), FFR<sub>CT</sub> was further analyzed. The Cox proportional hazards model was used to examine the association of FFR<sub>CT</sub> and cardiovascular risk factors with incident MACE within 2 years.<h4>Results</h4>Among 933 patients with available information on MACE within 2 years after enrollment, the incidence rate of MACE was higher in 281 patients with CAS than in those without CAS (6.11 vs. 1.16 per 100 patient-year). In 241 patients with CAS, the Cox proportional hazards analysis showed that FFR<sub>CT</sub> as well as diabetes mellitus and low high-density lipoprotein cholesterol level were independently associated with incident MACE. Moreover, the hazard ratio was significantly higher in patients harboring all three factors compared to those harboring 0-2 of the three factors (6.01; 95% confidence interval: 2.77-13.03).<h4>Conclusions</h4>Combinatorial assessment using CCTA for stenosis, FFR<sub>CT</sub> , and risk factors was useful for more accurate prediction of MACE in patients with suspected CAD. Among patients with CAS, those with lower FFR<sub>CT</sub> , diabetes mellitus, and low high-density lipoprotein cholesterol level were at highest risk for MACE during the 2-year period following enrollment."],"journal":["Clinical cardiology"],"pubmed_title":["Combination of coronary CT angiography, FFR<sub>CT</sub> , and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD."],"pmcid":["PMC10189082"],"funding_grant_id":["20gk0210026h001"],"pubmed_authors":["Nakai M","Noguchi T","Wada S","Iwanaga Y","Nakao YM","Miyamoto Y","NADESICO Study Investigators"],"additional_accession":[]},"is_claimable":false,"name":"Combination of coronary CT angiography, FFR<sub>CT</sub> , and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD.","description":"<h4>Background</h4>To examine the utility of fractional flow reserve by coronary computed tomography (CT) angiography (FFR<sub>CT</sub> ) for predicting major adverse cardiovascular events (MACE) in patients with suspected coronary artery disease (CAD).<h4>Methods</h4>This was a nationwide multicenter prospective cohort study including consecutive 1187 patients aged 50-74 years with suspected CAD and had available coronary CT angiography (CCTA). In patients with ≥50% coronary artery stenosis (CAS), FFR<sub>CT</sub> was further analyzed. The Cox proportional hazards model was used to examine the association of FFR<sub>CT</sub> and cardiovascular risk factors with incident MACE within 2 years.<h4>Results</h4>Among 933 patients with available information on MACE within 2 years after enrollment, the incidence rate of MACE was higher in 281 patients with CAS than in those without CAS (6.11 vs. 1.16 per 100 patient-year). In 241 patients with CAS, the Cox proportional hazards analysis showed that FFR<sub>CT</sub> as well as diabetes mellitus and low high-density lipoprotein cholesterol level were independently associated with incident MACE. Moreover, the hazard ratio was significantly higher in patients harboring all three factors compared to those harboring 0-2 of the three factors (6.01; 95% confidence interval: 2.77-13.03).<h4>Conclusions</h4>Combinatorial assessment using CCTA for stenosis, FFR<sub>CT</sub> , and risk factors was useful for more accurate prediction of MACE in patients with suspected CAD. Among patients with CAS, those with lower FFR<sub>CT</sub> , diabetes mellitus, and low high-density lipoprotein cholesterol level were at highest risk for MACE during the 2-year period following enrollment.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-05T16:14:22.215Z","creation":"2025-04-05T16:14:22.215Z"},"accession":"S-EPMC10189082","cross_references":{"pubmed":["36860175"],"doi":["10.1002/clc.23989"]}}