biostudies-literatureWada SJapan Agency for Medical Research and Development494-501https://www.ebi.ac.uk/biostudies/studies/S-EPMC10189082biostudies-literatureUnknown46(5)<h4>Background</h4>To examine the utility of fractional flow reserve by coronary computed tomography (CT) angiography (FFR_CT ) for predicting major adverse cardiovascular events (MACE) in patients with suspected coronary artery disease (CAD).<h4>Methods</h4>This was a nationwide multicenter prospective cohort study including consecutive 1187 patients aged 50-74 years with suspected CAD and had available coronary CT angiography (CCTA). In patients with ≥50% coronary artery stenosis (CAS), FFR_CT was further analyzed. The Cox proportional hazards model was used to examine the association of FFR_CT and cardiovascular risk factors with incident MACE within 2 years.<h4>Results</h4>Among 933 patients with available information on MACE within 2 years after enrollment, the incidence rate of MACE was higher in 281 patients with CAS than in those without CAS (6.11 vs. 1.16 per 100 patient-year). In 241 patients with CAS, the Cox proportional hazards analysis showed that FFR_CT as well as diabetes mellitus and low high-density lipoprotein cholesterol level were independently associated with incident MACE. Moreover, the hazard ratio was significantly higher in patients harboring all three factors compared to those harboring 0-2 of the three factors (6.01; 95% confidence interval: 2.77-13.03).<h4>Conclusions</h4>Combinatorial assessment using CCTA for stenosis, FFR_CT , and risk factors was useful for more accurate prediction of MACE in patients with suspected CAD. Among patients with CAS, those with lower FFR_CT , diabetes mellitus, and low high-density lipoprotein cholesterol level were at highest risk for MACE during the 2-year period following enrollment.Clinical cardiologyCombination of coronary CT angiography, FFR_CT , and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD.PMC1018908220gk0210026h001Nakai MNoguchi TWada SIwanaga YNakao YMMiyamoto YNADESICO Study InvestigatorsfalseCombination of coronary CT angiography, FFR_CT , and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD.<h4>Background</h4>To examine the utility of fractional flow reserve by coronary computed tomography (CT) angiography (FFR_CT ) for predicting major adverse cardiovascular events (MACE) in patients with suspected coronary artery disease (CAD).<h4>Methods</h4>This was a nationwide multicenter prospective cohort study including consecutive 1187 patients aged 50-74 years with suspected CAD and had available coronary CT angiography (CCTA). In patients with ≥50% coronary artery stenosis (CAS), FFR_CT was further analyzed. The Cox proportional hazards model was used to examine the association of FFR_CT and cardiovascular risk factors with incident MACE within 2 years.<h4>Results</h4>Among 933 patients with available information on MACE within 2 years after enrollment, the incidence rate of MACE was higher in 281 patients with CAS than in those without CAS (6.11 vs. 1.16 per 100 patient-year). In 241 patients with CAS, the Cox proportional hazards analysis showed that FFR_CT as well as diabetes mellitus and low high-density lipoprotein cholesterol level were independently associated with incident MACE. Moreover, the hazard ratio was significantly higher in patients harboring all three factors compared to those harboring 0-2 of the three factors (6.01; 95% confidence interval: 2.77-13.03).<h4>Conclusions</h4>Combinatorial assessment using CCTA for stenosis, FFR_CT , and risk factors was useful for more accurate prediction of MACE in patients with suspected CAD. Among patients with CAS, those with lower FFR_CT , diabetes mellitus, and low high-density lipoprotein cholesterol level were at highest risk for MACE during the 2-year period following enrollment.2023-01-01T00:00:00Z2023 May2025-04-05T16:14:22.215Z2025-04-05T16:14:22.215ZS-EPMC101890823686017510.1002/clc.23989