{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang X"],"funding":["Science and Technology Department of Sichuan Province","National Natural Science Foundation of China","University of Texas MD Anderson Cancer Center"],"pagination":["e15939"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10189240"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(5)"],"pubmed_abstract":["BRAF mutation plays an important role in the pathogenesis and progression of melanoma and is correlated to the prognosis of melanoma patients. However, fewer studies have attempted to develop a BRAF mutation-associated gene risk model for predicting the prognosis of melanoma. The current research explores BRAF mutation-related biological features in melanoma and establishes a prognostic signature. First, we identified three significantly enriched KEGG pathways (glycosphingolipid biosynthesis - ganglio series, ether lipid metabolism, and glycosaminoglycan biosynthesis - keratan sulfate) and corresponding genes in the BRAF mutant group by gene set enrichment analysis. We then developed a prognostic signature based on 7 BRAF-associated genes (PLA2G2D, FUT8, PLA2G4E, PLA2G5, PLA2G1B, B3GNT2, a"],"journal":["Heliyon"],"pubmed_title":["A BRAF mutation-associated gene risk model for predicting the prognosis of melanoma."],"pmcid":["PMC10189240"],"funding_grant_id":["PD-L1","38–41","PD-1"],"pubmed_authors":["Huang Y","Feng J","Huang X","Song Q","Jiang X","Gou W","Wen C","Bo X","Gao H"],"additional_accession":[]},"is_claimable":false,"name":"A BRAF mutation-associated gene risk model for predicting the prognosis of melanoma.","description":"BRAF mutation plays an important role in the pathogenesis and progression of melanoma and is correlated to the prognosis of melanoma patients. However, fewer studies have attempted to develop a BRAF mutation-associated gene risk model for predicting the prognosis of melanoma. The current research explores BRAF mutation-related biological features in melanoma and establishes a prognostic signature. First, we identified three significantly enriched KEGG pathways (glycosphingolipid biosynthesis - ganglio series, ether lipid metabolism, and glycosaminoglycan biosynthesis - keratan sulfate) and corresponding genes in the BRAF mutant group by gene set enrichment analysis. We then developed a prognostic signature based on 7 BRAF-associated genes (PLA2G2D, FUT8, PLA2G4E, PLA2G5, PLA2G1B, B3GNT2, a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-05-28T10:49:19.694Z","creation":"2024-11-19T16:22:11.37Z"},"accession":"S-EPMC10189240","cross_references":{"pubmed":["37205993"],"doi":["10.1016/j.heliyon.2023.e15939"]}}