biostudies-literatureHuang XScience and Technology Department of Sichuan ProvinceNational Natural Science Foundation of ChinaUniversity of Texas MD Anderson Cancer Centere15939https://www.ebi.ac.uk/biostudies/studies/S-EPMC10189240biostudies-literatureUnknown9(5)BRAF mutation plays an important role in the pathogenesis and progression of melanoma and is correlated to the prognosis of melanoma patients. However, fewer studies have attempted to develop a BRAF mutation-associated gene risk model for predicting the prognosis of melanoma. The current research explores BRAF mutation-related biological features in melanoma and establishes a prognostic signature. First, we identified three significantly enriched KEGG pathways (glycosphingolipid biosynthesis - ganglio series, ether lipid metabolism, and glycosaminoglycan biosynthesis - keratan sulfate) and corresponding genes in the BRAF mutant group by gene set enrichment analysis. We then developed a prognostic signature based on 7 BRAF-associated genes (PLA2G2D, FUT8, PLA2G4E, PLA2G5, PLA2G1B, B3GNT2, aHeliyonA BRAF mutation-associated gene risk model for predicting the prognosis of melanoma.PMC10189240PD-L138–41PD-1Huang YFeng JHuang XSong QJiang XGou WWen CBo XGao HfalseA BRAF mutation-associated gene risk model for predicting the prognosis of melanoma.BRAF mutation plays an important role in the pathogenesis and progression of melanoma and is correlated to the prognosis of melanoma patients. However, fewer studies have attempted to develop a BRAF mutation-associated gene risk model for predicting the prognosis of melanoma. The current research explores BRAF mutation-related biological features in melanoma and establishes a prognostic signature. First, we identified three significantly enriched KEGG pathways (glycosphingolipid biosynthesis - ganglio series, ether lipid metabolism, and glycosaminoglycan biosynthesis - keratan sulfate) and corresponding genes in the BRAF mutant group by gene set enrichment analysis. We then developed a prognostic signature based on 7 BRAF-associated genes (PLA2G2D, FUT8, PLA2G4E, PLA2G5, PLA2G1B, B3GNT2, a2023-01-01T00:00:00Z2023 May2026-05-28T10:49:19.694Z2024-11-19T16:22:11.37ZS-EPMC101892403720599310.1016/j.heliyon.2023.e15939